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AKTIP

CANCER ATLAS

Gene description

 AKT interacting protein

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041794
HPA046300

GENE INFORMATION

Gene name

 AKTIP (HGNC Symbol)

Synonyms

 FLJ13258, FTS

Description

 AKT interacting protein (HGNC Symbol)

Entrez gene summary

 The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q12.2

Chromosome location (bp)

 53491040 - 53504411

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166971 (version 83.38)

Entrez gene

 64400

UniProt

 Q9H8T0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H8T0

Antibodypedia

 AKTIP antibodies

PROTEIN BROWSER
AKTIP-001
AKTIP-002
AKTIP-003
AKTIP-005
AKTIP-006
AKTIP-007
AKTIP-008
AKTIP-009
AKTIP-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKTIP-001
ENSP00000378152
ENST00000394657
Q9H8T0 [Direct mapping]
AKT-interacting protein
A0A024R6T5 [Target identity:100%; Query identity:100%]
Fused toes homolog (Mouse), isoform CRA_b
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0007032 [endosome organization]
GO:0007040 [lysosome organization]
GO:0008333 [endosome to lysosome transport]
GO:0015031 [protein transport]
GO:0016567 [protein ubiquitination]
GO:0030897 [HOPS complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032092 [positive regulation of protein binding]
GO:0045022 [early endosome to late endosome transport]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070695 [FHF complex]
Show all
 292 aa
33.1 kDa 		No 0
AKTIP-002
ENSP00000455874
ENST00000570004
Q9H8T0 [Direct mapping]
AKT-interacting protein
A0A024R6T5 [Target identity:100%; Query identity:100%]
Fused toes homolog (Mouse), isoform CRA_b
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0007032 [endosome organization]
GO:0007040 [lysosome organization]
GO:0008333 [endosome to lysosome transport]
GO:0015031 [protein transport]
GO:0016567 [protein ubiquitination]
GO:0030897 [HOPS complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032092 [positive regulation of protein binding]
GO:0045022 [early endosome to late endosome transport]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070695 [FHF complex]
Show all
 292 aa
33.1 kDa 		No 0
AKTIP-003
ENSP00000300245
ENST00000300245
Q9H8T0 [Direct mapping]
AKT-interacting protein
A0A024R6S6 [Target identity:100%; Query identity:100%]
Fused toes homolog (Mouse), isoform CRA_c
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0007032 [endosome organization]
GO:0007040 [lysosome organization]
GO:0008333 [endosome to lysosome transport]
GO:0015031 [protein transport]
GO:0016567 [protein ubiquitination]
GO:0030897 [HOPS complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032092 [positive regulation of protein binding]
GO:0045022 [early endosome to late endosome transport]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070695 [FHF complex]
Show all
 293 aa
33.3 kDa 		No 0
AKTIP-005
ENSP00000456398
ENST00000564497
H3BRT7 [Direct mapping]
AKT-interacting protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016567 [protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 14 aa
1.7 kDa 		No 0
AKTIP-006
ENSP00000454269
ENST00000568022
H3BM79 [Direct mapping]
AKT-interacting protein
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016567 [protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 249 aa
28 kDa 		No 0
AKTIP-007
ENSP00000454771
ENST00000568596
H3BNB8 [Direct mapping]
AKT-interacting protein
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016567 [protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 127 aa
14.2 kDa 		No 0
AKTIP-008
ENSP00000458118
ENST00000565408
H3BVH0 [Direct mapping]
AKT-interacting protein
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016567 [protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 136 aa
15.1 kDa 		No 0
AKTIP-009
ENSP00000456922
ENST00000570041
H3BSX7 [Direct mapping]
AKT-interacting protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016567 [protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 40 aa
4.5 kDa 		No 0
AKTIP-010
ENSP00000456418
ENST00000563928
H3BRV2 [Direct mapping]
AKT-interacting protein
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016567 [protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 150 aa
16.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.