We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific] GO:0001047 [core promoter binding] GO:0001655 [urogenital system development] GO:0001656 [metanephros development] GO:0001756 [somitogenesis] GO:0001934 [positive regulation of protein phosphorylation] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004882 [androgen receptor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007275 [multicellular organismal development] GO:0007431 [salivary gland development] GO:0007507 [heart development] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008584 [male gonad development] GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010942 [positive regulation of cell death] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0030284 [estrogen receptor activity] GO:0030295 [protein kinase activator activity] GO:0030331 [estrogen receptor binding] GO:0030521 [androgen receptor signaling pathway] GO:0030850 [prostate gland development] GO:0032147 [activation of protein kinase activity] GO:0033574 [response to testosterone] GO:0035690 [cellular response to drug] GO:0035907 [dorsal aorta development] GO:0042826 [histone deacetylase binding] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043491 [protein kinase B signaling] GO:0043565 [sequence-specific DNA binding] GO:0043569 [negative regulation of insulin-like growth factor receptor signaling pathway] GO:0043621 [protein self-association] GO:0044212 [transcription regulatory region DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0051781 [positive regulation of cell division] GO:0060037 [pharyngeal system development] GO:0060442 [branching involved in prostate gland morphogenesis] GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis] GO:0060770 [negative regulation of epithelial cell proliferation involved in prostate gland development] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] GO:0071383 [cellular response to steroid hormone stimulus] GO:0071456 [cellular response to hypoxia] GO:0071850 [mitotic cell cycle arrest] GO:0071899 [negative regulation of estrogen receptor binding] GO:0097162 [MADS box domain binding] GO:2000836 [positive regulation of androgen secretion] GO:2001022 [positive regulation of response to DNA damage stimulus] GO:2001235 [positive regulation of apoptotic signaling pathway] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]