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This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
P35232 [Direct mapping] Prohibitin A8K401 [Target identity:100%; Query identity:100%] Prohibitin, isoform CRA_a; cDNA FLJ78511, highly similar to Homo sapiens prohibitin (PHB), mRNA; cDNA, FLJ93035, Homo sapiens prohibitin (PHB), mRNA
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MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001649 [osteoblast differentiation] GO:0001850 [complement component C3a binding] GO:0001851 [complement component C3b binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0007005 [mitochondrion organization] GO:0007165 [signal transduction] GO:0008022 [protein C-terminus binding] GO:0008285 [negative regulation of cell proliferation] GO:0009986 [cell surface] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016020 [membrane] GO:0016575 [histone deacetylation] GO:0019899 [enzyme binding] GO:0030308 [negative regulation of cell growth] GO:0031871 [proteinase activated receptor binding] GO:0042177 [negative regulation of protein catabolic process] GO:0042826 [histone deacetylase binding] GO:0042981 [regulation of apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045917 [positive regulation of complement activation] GO:0050821 [protein stabilization] GO:0050847 [progesterone receptor signaling pathway] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071354 [cellular response to interleukin-6] GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]