Cell atlas - DOLPP1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

DOLPP1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Intermediate filaments
	Vesicles

Human cell
	Intermediate Filaments
	Vesicles

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	DOLPP1
Gene description	Dolichyldiphosphatase 1
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the intermediate filaments.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Additional location	In addition localized to the Intermediate filaments (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA019179
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the intermediate filaments.

Main location

Vesicles (approved)

Additional location

Intermediate filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA019179	A-431	Vesicles
	HPA019179	U-2 OS	Vesicles
	HPA019179	U-2 OS	Intermediate filaments
	HPA019179	U-251 MG	Vesicles
	HPA019179	U-251 MG	Intermediate filaments

GENE INFORMATION
Gene name	DOLPP1 (HGNC Symbol)
Synonyms	LSFR2
Description	Dolichyldiphosphatase 1 (HGNC Symbol)
Entrez gene summary	A similar gene has been characterized in mice and encodes dolichyl pyrophosphate (Dol-P-P) phosphatase. This protein dephosphorylates dolichyl pyrophosphate so that it may be re-utilized as a glycosyl carrier lipid by the oligosaccharyltransferase multisubunit complex in the ER. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
Chromosome	9
Cytoband	q34.11
Chromosome location (bp)	129081100 - 129090438
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167130 (version 83.38)
Entrez gene	57171
UniProt	Q86YN1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q86YN1
Antibodypedia	DOLPP1 antibodies

PROTEIN BROWSER

DOLPP1-001	DOLPP1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DOLPP1-001 ENSP00000361625 ENST00000372546	Q86YN1 [Direct mapping] Dolichyldiphosphatase 1 A0A024R8B5 [Target identity:100%; Query identity:100%] Dolichyl pyrophosphate phosphatase 1, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006487 [protein N-linked glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006489 [dolichyl diphosphate biosynthetic process] GO:0008610 [lipid biosynthetic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0047874 [dolichyldiphosphatase activity] Show all	238 aa 27 kDa	No	4
DOLPP1-003 ENSP00000384043 ENST00000406974	Q86YN1 [Direct mapping] Dolichyldiphosphatase 1 A0A0A6YYB0 [Direct mapping] Dolichyldiphosphatase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006487 [protein N-linked glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006489 [dolichyl diphosphate biosynthetic process] GO:0008610 [lipid biosynthetic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0047874 [dolichyldiphosphatase activity] Show all	195 aa 22.1 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.