Expression of PRRX2 in cancer - Summary

CANCER ATLAS

Gene description

Paired related homeobox 2

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA026808

GENE INFORMATION
Gene name	PRRX2 (HGNC Symbol)
Synonyms	PMX2, PRX2
Description	Paired related homeobox 2 (HGNC Symbol)
Entrez gene summary	The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q34.11
Chromosome location (bp)	129665641 - 129722674
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000167157 (version 83.38)
Entrez gene	51450
UniProt	Q99811 (UniProt - Evidence at transcript level)
neXtProt	NX_Q99811
Antibodypedia	PRRX2 antibodies

PROTEIN BROWSER

PRRX2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRRX2-001 ENSP00000361547 ENST00000372469	Q99811 [Direct mapping] Paired mesoderm homeobox protein 2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0030326 [embryonic limb morphogenesis] GO:0042472 [inner ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0043565 [sequence-specific DNA binding] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0048701 [embryonic cranial skeleton morphogenesis] GO:0048704 [embryonic skeletal system morphogenesis] GO:0048844 [artery morphogenesis] GO:0051216 [cartilage development] Show all	253 aa 27.1 kDa	No	0