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Most cancer tissues showed weak to moderate cytoplasmic positivity. Few colorectal, cancers displayed strong immunoreactivity. Gliomas, head neck cancers along with several lung and liver cancers were negative.
The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001306 [age-dependent response to oxidative stress] GO:0001701 [in utero embryonic development] GO:0001841 [neural tube formation] GO:0003682 [chromatin binding] GO:0004497 [monooxygenase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006744 [ubiquinone biosynthetic process] GO:0006979 [response to oxidative stress] GO:0008340 [determination of adult lifespan] GO:0022008 [neurogenesis] GO:0022904 [respiratory electron transport chain] GO:0034599 [cellular response to oxidative stress] GO:0042493 [response to drug] GO:0042775 [mitochondrial ATP synthesis coupled electron transport] GO:0044281 [small molecule metabolic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] GO:0070584 [mitochondrion morphogenesis] GO:2000377 [regulation of reactive oxygen species metabolic process]
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003682 [chromatin binding] GO:0004497 [monooxygenase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006744 [ubiquinone biosynthetic process] GO:0042775 [mitochondrial ATP synthesis coupled electron transport] GO:0044281 [small molecule metabolic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] GO:2000377 [regulation of reactive oxygen species metabolic process]
