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CD3D

GENERAL INFORMATION

Gene name

 CD3D

Gene description

 CD3d molecule, delta (CD3-TCR complex)

Protein class

 CD markers
Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node, tonsil)
GTEx:Group enriched (spleen, small intestine, lung)
FANTOM5:Tissue enhanced (tonsil, lymph node, appendix)

Protein evidence

 Evidence at protein level

Protein expression

 High cytoplasmic expression in a subset of immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
CAB013055
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, small intestine, lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (tonsil, lymph node, appendix)

GENE INFORMATION

Gene name

 CD3D (HGNC Symbol)

Synonyms

 T3D

Description

 CD3d molecule, delta (CD3-TCR complex) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 118338954 - 118342744

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167286 (version 83.38)

Entrez gene

 915

UniProt

 P04234 (UniProt - Evidence at protein level)

neXtProt

 NX_P04234

Antibodypedia

 CD3D antibodies

PROTEIN BROWSER
CD3D-001
CD3D-002
CD3D-003
CD3D-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD3D-001
ENSP00000300692
ENST00000300692
P04234 [Direct mapping]
T-cell surface glycoprotein CD3 delta chain
B0YIY4 [Target identity:100%; Query identity:100%]
CD3d antigen, delta polypeptide (TiT3 complex), isoform CRA_a; T-cell surface glycoprotein CD3 delta chain; cDNA, FLJ92244, Homo sapiens CD3D antigen, delta polypeptide (TiT3 complex) (CD3D),mRNA
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030217 [T cell differentiation]
GO:0031295 [T cell costimulation]
GO:0042101 [T cell receptor complex]
GO:0042105 [alpha-beta T cell receptor complex]
GO:0045059 [positive thymic T cell selection]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0050776 [regulation of immune response]
GO:0050852 [T cell receptor signaling pathway]
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 171 aa
18.9 kDa 		Yes 1
CD3D-002
ENSP00000437335
ENST00000529594
E9PMT5 [Direct mapping]
CD3 delta; T-cell surface glycoprotein CD3 delta chain
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0007166 [cell surface receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 98 aa
10.5 kDa 		Yes 1
CD3D-003
ENSP00000376622
ENST00000392884
P04234 [Direct mapping]
T-cell surface glycoprotein CD3 delta chain
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CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030217 [T cell differentiation]
GO:0031295 [T cell costimulation]
GO:0042101 [T cell receptor complex]
GO:0045059 [positive thymic T cell selection]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0050776 [regulation of immune response]
GO:0050852 [T cell receptor signaling pathway]
Show all
 127 aa
14.5 kDa 		Yes 0
CD3D-005
ENSP00000434794
ENST00000534687
H0YE18 [Direct mapping]
T-cell surface glycoprotein CD3 delta chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0007166 [cell surface receptor signaling pathway]
GO:0016020 [membrane]
Show all
 132 aa
15 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.