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RRM1

CANCER ATLAS

Gene description

 Ribonucleotide reductase M1

Protein class

 Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA057265
HPA064297
CAB022093

GENE INFORMATION

Gene name

 RRM1

Synonyms

Description

 Ribonucleotide reductase M1 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 4094707 - 4138876

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167325 (version 83.38)

Entrez gene

 6240

UniProt

 P23921 (UniProt - Evidence at protein level)

neXtProt

 NX_P23921

Antibodypedia

 RRM1 antibodies

PROTEIN BROWSER
RRM1-001
RRM1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RRM1-001
ENSP00000300738
ENST00000300738
P23921 [Direct mapping]
Ribonucleoside-diphosphate reductase large subunit
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0004748 [ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005971 [ribonucleoside-diphosphate reductase complex]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006260 [DNA replication]
GO:0008584 [male gonad development]
GO:0009263 [deoxyribonucleotide biosynthetic process]
GO:0010212 [response to ionizing radiation]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0017076 [purine nucleotide binding]
GO:0021846 [cell proliferation in forebrain]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0044281 [small molecule metabolic process]
GO:0051259 [protein oligomerization]
GO:0051290 [protein heterotetramerization]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0060041 [retina development in camera-type eye]
GO:0070062 [extracellular exosome]
Show all
 792 aa
90.1 kDa 		No 0
RRM1-005
ENSP00000431464
ENST00000534285
E9PL69 [Direct mapping]
Ribonucleoside-diphosphate reductase large subunit
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006260 [DNA replication]
GO:0055114 [oxidation-reduction process]
Show all
 570 aa
64.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.