Tissue expression of PPP2R3B - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PPP2R3B
Gene description	Protein phosphatase 2, regulatory subunit B'', beta
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (skeletal muscle)
GTEx:	Expressed in all
FANTOM5:	Tissue enhanced (pituitary gland)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skeletal muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pituitary gland)

GENE INFORMATION
Gene name	PPP2R3B (HGNC Symbol)
Synonyms	PPP2R3L, PPP2R3LY, PR48
Description	Protein phosphatase 2, regulatory subunit B'', beta (HGNC Symbol)
Entrez gene summary	Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]
Chromosome	X
Cytoband	p22.33
Chromosome location (bp)	333963 - 386955
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167393 (version 83.38)
Entrez gene	28227
UniProt	Q9Y5P8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5P8
Antibodypedia	PPP2R3B antibodies

PROTEIN BROWSER

PPP2R3B-001	PPP2R3B-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPP2R3B-001 ENSP00000375080 ENST00000390665	Q9Y5P8 [Direct mapping] Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000159 [protein phosphatase type 2A complex] GO:0000278 [mitotic cell cycle] GO:0003682 [chromatin binding] GO:0004721 [phosphoprotein phosphatase activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006470 [protein dephosphorylation] GO:0007050 [cell cycle arrest] GO:0008285 [negative regulation of cell proliferation] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] Show all	575 aa 65.1 kDa	No	0
PPP2R3B-002 ENSP00000371038 ENST00000381625	C9JMU6 [Direct mapping] Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		169 aa 18.8 kDa	No	0