Tissue expression of CA4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CA4
Gene description	Carbonic anhydrase IV
Protein class	Disease related genes Enzymes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (colon, rectum)
GTEx:	Tissue enhanced (cerebellum)
FANTOM5:	Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

Protein expression

Membranous expression in glandular cells in gastrointestinal tract. Additional positivity in endothelial cells in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA011089 , HPA017258
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (colon, rectum)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION
Gene name	CA4 (HGNC Symbol)
Synonyms	CAIV, Car4, RP17
Description	Carbonic anhydrase IV (HGNC Symbol)
Entrez gene summary	Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q23.1
Chromosome location (bp)	60149936 - 60170899
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167434 (version 83.38)
Entrez gene	762
UniProt	P22748 (UniProt - Evidence at protein level)
neXtProt	NX_P22748
Antibodypedia	CA4 antibodies

PROTEIN BROWSER

CA4-001	CA4-003	CA4-005	CA4-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CA4-001 ENSP00000300900 ENST00000300900	P22748 [Direct mapping] Carbonic anhydrase 4 Show all	Enzymes ENZYME proteins Lyases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005515 [protein binding] GO:0005791 [rough endoplasmic reticulum] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] GO:0009986 [cell surface] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0030658 [transport vesicle membrane] GO:0030667 [secretory granule membrane] GO:0031362 [anchored component of external side of plasma membrane] GO:0031526 [brush border membrane] GO:0044281 [small molecule metabolic process] GO:0046658 [anchored component of plasma membrane] GO:0048471 [perinuclear region of cytoplasm] GO:0070062 [extracellular exosome] Show all	312 aa 35 kDa	Yes	1
CA4-003 ENSP00000466964 ENST00000591725	K7ENI8 [Direct mapping] Carbonic anhydrase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0031225 [anchored component of membrane] Show all	38 aa 4.2 kDa	No	0
CA4-005 ENSP00000465837 ENST00000590203	K7EKY5 [Direct mapping] Carbonic anhydrase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0031225 [anchored component of membrane] Show all	184 aa 20.7 kDa	No	1
CA4-006 ENSP00000464757 ENST00000587265	K7EIH9 [Direct mapping] Carbonic anhydrase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0031225 [anchored component of membrane] Show all	99 aa 11.4 kDa	No	0