Expression of GPX4 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Glutathione peroxidase 4

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA047224	HPA058546	CAB008630

GENE INFORMATION
Gene name	GPX4 (HGNC Symbol)
Synonyms	MCSP, PHGPx
Description	Glutathione peroxidase 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	1103926 - 1106791
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167468 (version 83.38)
Entrez gene	2879
UniProt	P36969 (UniProt - Evidence at protein level)
neXtProt	NX_P36969
Antibodypedia	GPX4 antibodies

PROTEIN BROWSER

GPX4-002	GPX4-003	GPX4-004	GPX4-006	GPX4-007	GPX4-009	GPX4-010	GPX4-011	GPX4-201	GPX4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPX4-002 ENSP00000346103 ENST00000354171	P36969 [Direct mapping] Phospholipid hydroperoxide glutathione peroxidase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005829 [cytosol] GO:0006325 [chromatin organization] GO:0006644 [phospholipid metabolic process] GO:0006979 [response to oxidative stress] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0019369 [arachidonic acid metabolic process] GO:0019372 [lipoxygenase pathway] GO:0044281 [small molecule metabolic process] GO:0047066 [phospholipid-hydroperoxide glutathione peroxidase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	197 aa 22.2 kDa	Yes	0
GPX4-003 ENSP00000464989 ENST00000588919	K7EJ20 [Direct mapping] Glutathione peroxidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0006979 [response to oxidative stress] GO:0055114 [oxidation-reduction process] Show all	242 aa 26.9 kDa	No	0
GPX4-004 ENSP00000473614 ENST00000585362	R4GNE4 [Direct mapping] Glutathione peroxidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0006979 [response to oxidative stress] GO:0055114 [oxidation-reduction process] Show all	180 aa 20.7 kDa	No	0
GPX4-006 ENSP00000465828 ENST00000593032	K7EKX7 [Direct mapping] Glutathione peroxidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0006979 [response to oxidative stress] GO:0055114 [oxidation-reduction process] Show all	175 aa 19.9 kDa	No	0
GPX4-007 ENSP00000466872 ENST00000589115	K7ENB4 [Direct mapping] Glutathione peroxidase Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0006979 [response to oxidative stress] GO:0055114 [oxidation-reduction process] Show all	180 aa 20.1 kDa	Yes	0
GPX4-009 ENSP00000468349 ENST00000587648	K7ERP4 [Direct mapping] Glutathione peroxidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0006979 [response to oxidative stress] GO:0055114 [oxidation-reduction process] Show all	155 aa 17.7 kDa	No	0
GPX4-010 ENSP00000484697 ENST00000614791	A0A087X247 [Direct mapping] Glutathione peroxidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0006979 [response to oxidative stress] GO:0055114 [oxidation-reduction process] Show all	134 aa 15.5 kDa	No	0
GPX4-011 ENSP00000483655 ENST00000611653	P36969 [Direct mapping] Phospholipid hydroperoxide glutathione peroxidase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006644 [phospholipid metabolic process] GO:0006979 [response to oxidative stress] GO:0007275 [multicellular organismal development] GO:0019369 [arachidonic acid metabolic process] GO:0019372 [lipoxygenase pathway] GO:0044281 [small molecule metabolic process] GO:0047066 [phospholipid-hydroperoxide glutathione peroxidase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	170 aa 19.5 kDa	No	0
GPX4-201 ENSP00000485000 ENST00000616066	A0A087X2I2 [Direct mapping] Glutathione peroxidase Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0006979 [response to oxidative stress] GO:0055114 [oxidation-reduction process] Show all	196 aa 22 kDa	Yes	0
GPX4-202 ENSP00000477503 ENST00000622390	A0A087WT12 [Direct mapping] Glutathione peroxidase Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0006979 [response to oxidative stress] GO:0055114 [oxidation-reduction process] Show all	233 aa 26.9 kDa	No	0