Cell atlas - CDT1 - The Human Protein Atlas

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CDT1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CDT1
Gene description	Chromatin licensing and DNA replication factor 1
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the nuclear bodies.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)
Additional location	In addition localized to the Nuclear bodies (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA017224
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the nuclear bodies.

Main location

Nucleus (supported)

Additional location

Nuclear bodies (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017224	A-431	Nucleoplasm
	HPA017224	U-2 OS	Nucleus
	HPA017224	U-251 MG	Nucleoplasm
	HPA017224	U-251 MG	Nuclear bodies

GENE INFORMATION
Gene name	CDT1 (HGNC Symbol)
Synonyms	DUP, RIS2
Description	Chromatin licensing and DNA replication factor 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]
Chromosome	16
Cytoband	q24.3
Chromosome location (bp)	88803213 - 88809258
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167513 (version 83.38)
Entrez gene	81620
UniProt	Q9H211 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H211
Antibodypedia	CDT1 antibodies

PROTEIN BROWSER

CDT1-001	CDT1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDT1-001 ENSP00000301019 ENST00000301019	Q9H211 [Direct mapping] DNA replication factor Cdt1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000076 [DNA replication checkpoint] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0030174 [regulation of DNA-dependent DNA replication initiation] GO:0033262 [regulation of nuclear cell cycle DNA replication] Show all	546 aa 60.4 kDa	No	0
CDT1-002 ENSP00000456926 ENST00000569140	H3BSY1 [Direct mapping] DNA replication factor Cdt1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		190 aa 20.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.