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GPD1

GENERAL INFORMATION

Gene name

 GPD1

Gene description

 Glycerol-3-phosphate dehydrogenase 1 (soluble)

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adipose tissue, skeletal muscle)
GTEx:Tissue enhanced (adipose tissue, breast)
FANTOM5:Tissue enhanced (adipose tissue)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA044620
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue, skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue, breast)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue)

GENE INFORMATION

Gene name

 GPD1

Synonyms

Description

 Glycerol-3-phosphate dehydrogenase 1 (soluble) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 50103819 - 50111319

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167588 (version 83.38)

Entrez gene

 2819

UniProt

 P21695 (UniProt - Evidence at protein level)

neXtProt

 NX_P21695

Antibodypedia

 GPD1 antibodies

PROTEIN BROWSER
GPD1-001
GPD1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPD1-001
ENSP00000301149
ENST00000301149
P21695 [Direct mapping]
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
A0A024R138 [Target identity:100%; Query identity:100%]
Glycerol-3-phosphate dehydrogenase [NAD(+)]
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004367 [glycerol-3-phosphate dehydrogenase [NAD+] activity]
GO:0004368 [glycerol-3-phosphate dehydrogenase activity]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006072 [glycerol-3-phosphate metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006116 [NADH oxidation]
GO:0006127 [glycerophosphate shuttle]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0006734 [NADH metabolic process]
GO:0009331 [glycerol-3-phosphate dehydrogenase complex]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019432 [triglyceride biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045821 [positive regulation of glycolytic process]
GO:0046168 [glycerol-3-phosphate catabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0046486 [glycerolipid metabolic process]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071320 [cellular response to cAMP]
GO:0071356 [cellular response to tumor necrosis factor]
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 349 aa
37.6 kDa 		No 0
GPD1-002
ENSP00000446768
ENST00000548814
P21695 [Direct mapping]
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004367 [glycerol-3-phosphate dehydrogenase [NAD+] activity]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006072 [glycerol-3-phosphate metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0009331 [glycerol-3-phosphate dehydrogenase complex]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019432 [triglyceride biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046168 [glycerol-3-phosphate catabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 326 aa
35.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.