Cell atlas - CYP2S1 - The Human Protein Atlas

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CYP2S1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	CYP2S1
Gene description	Cytochrome P450, family 2, subfamily S, polypeptide 1
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Cell line enhanced (A549, NTERA-2, HaCaT, CACO-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved)
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA049227
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A549, NTERA-2, HaCaT, CACO-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA049227	A549	No staining
	HPA049227	CACO-2	No staining
	HPA049227	U-2 OS	Endoplasmic reticulum

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000040703 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA049227	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	CYP2S1
Synonyms
Description	Cytochrome P450, family 2, subfamily S, polypeptide 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	41193049 - 41207539
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167600 (version 83.38)
Entrez gene	29785
UniProt	Q96SQ9 (UniProt - Evidence at protein level)
neXtProt	NX_Q96SQ9
Antibodypedia	CYP2S1 antibodies

PROTEIN BROWSER

CYP2S1-001	CYP2S1-004	CYP2S1-005	CYP2S1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYP2S1-001 ENSP00000308032 ENST00000310054	Q96SQ9 [Direct mapping] Cytochrome P450 2S1 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0008392 [arachidonic acid epoxygenase activity] GO:0008395 [steroid hydroxylase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen] GO:0019373 [epoxygenase P450 pathway] GO:0019825 [oxygen binding] GO:0020037 [heme binding] GO:0042738 [exogenous drug catabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070330 [aromatase activity] Show all	504 aa 55.8 kDa	Yes	1
CYP2S1-004 ENSP00000471637 ENST00000597754	M0R152 [Direct mapping] Cytochrome P450 2S1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005737 [cytoplasm] GO:0006805 [xenobiotic metabolic process] GO:0008392 [arachidonic acid epoxygenase activity] GO:0008395 [steroid hydroxylase activity] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen] GO:0019373 [epoxygenase P450 pathway] GO:0019825 [oxygen binding] GO:0020037 [heme binding] GO:0042738 [exogenous drug catabolic process] GO:0055114 [oxidation-reduction process] Show all	175 aa 19.3 kDa	Yes	1
CYP2S1-005 ENSP00000469850 ENST00000593890	M0QYI2 [Direct mapping] Cytochrome P450 2S1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0006805 [xenobiotic metabolic process] GO:0008392 [arachidonic acid epoxygenase activity] GO:0008395 [steroid hydroxylase activity] GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen] GO:0019373 [epoxygenase P450 pathway] GO:0019825 [oxygen binding] GO:0020037 [heme binding] GO:0042738 [exogenous drug catabolic process] GO:0055114 [oxidation-reduction process] Show all	73 aa 7.9 kDa	No	0
CYP2S1-006 ENSP00000471016 ENST00000600561	M0R057 [Direct mapping] Cytochrome P450 2S1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005737 [cytoplasm] GO:0006805 [xenobiotic metabolic process] GO:0008392 [arachidonic acid epoxygenase activity] GO:0008395 [steroid hydroxylase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen] GO:0019373 [epoxygenase P450 pathway] GO:0019825 [oxygen binding] GO:0020037 [heme binding] GO:0042738 [exogenous drug catabolic process] GO:0055114 [oxidation-reduction process] Show all	187 aa 20.5 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.