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Several melanomas and gliomas displayed moderate to strong cytoplasmic positivity. Several seminomas and carcinoids along with a few urothelial cancers showed weak to moderate staining. Remaining cancer cells were negative.
Thyroid cancers showed strong cytoplasmic immunoreactivity. Several endometrial cancers along with rare cervical, renal and ovarian cancers were moderate to strongly stained. Remaining cancer tissues were weakly stained or generally negative.
GENE INFORMATION
Gene name
AXL (HGNC Symbol)
Synonyms
ARK, JTK11, Tyro7, UFO
Description
AXL receptor tyrosine kinase (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]