Cell atlas - LAIR1 - The Human Protein Atlas

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LAIR1

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	LAIR1
Gene description	Leukocyte-associated immunoglobulin-like receptor 1
Protein class	CD markers Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Cell line enhanced (THP-1, Karpas-707, HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA011155
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (THP-1, Karpas-707, HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA011155	A-431	Plasma membrane
	HPA011155	U-2 OS	Plasma membrane
	HPA011155	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	LAIR1 (HGNC Symbol)
Synonyms	CD305
Description	Leukocyte-associated immunoglobulin-like receptor 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Chromosome	19
Cytoband	q13.42
Chromosome location (bp)	54351384 - 54370558
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167613 (version 83.38)
Entrez gene	3903
UniProt	Q6GTX8 (UniProt - Evidence at protein level)
neXtProt	NX_Q6GTX8
Antibodypedia	LAIR1 antibodies

PROTEIN BROWSER

LAIR1-001	LAIR1-002	LAIR1-003	LAIR1-004	LAIR1-005	LAIR1-015	LAIR1-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LAIR1-001 ENSP00000375622 ENST00000391742	Q6GTX8 [Direct mapping] Leukocyte-associated immunoglobulin-like receptor 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	287 aa 31.5 kDa	Yes	1
LAIR1-002 ENSP00000391003 ENST00000434277	D3YTC8 [Direct mapping] Leukocyte-associated immunoglobulin-like receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	286 aa 31.3 kDa	Yes	1
LAIR1-003 ENSP00000301193 ENST00000348231	Q6GTX8 [Direct mapping] Leukocyte-associated immunoglobulin-like receptor 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	270 aa 29.9 kDa	Yes	1
LAIR1-004 ENSP00000418998 ENST00000474878	Q6GTX8 [Direct mapping] Leukocyte-associated immunoglobulin-like receptor 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	269 aa 29.8 kDa	Yes	1
LAIR1-005 ENSP00000375623 ENST00000391743	A8MZ84 [Direct mapping] Leukocyte-associated immunoglobulin-like receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	269 aa 29.7 kDa	No	1
LAIR1-015 ENSP00000392058 ENST00000438193	C9IZB2 [Direct mapping] Leukocyte-associated immunoglobulin-like receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	93 aa 10.3 kDa	No	0
LAIR1-016 ENSP00000483867 ENST00000622064	A0A087X137 [Direct mapping] Leukocyte-associated immunoglobulin-like receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		79 aa 8.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.