Expression of PSCA in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Prostate stem cell antigen

Protein class

Cancer-related genes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA056418

GENE INFORMATION
Gene name	PSCA
Synonyms
Description	Prostate stem cell antigen (HGNC Symbol)
Entrez gene summary	This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	142670308 - 142682724
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167653 (version 83.38)
Entrez gene	8000
UniProt	O43653 (UniProt - Evidence at protein level)
neXtProt	NX_O43653
Antibodypedia	PSCA antibodies

PROTEIN BROWSER

PSCA-001	PSCA-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PSCA-001 ENSP00000301258 ENST00000301258	O43653 [Direct mapping] Prostate stem cell antigen D3DWI6 [Target identity:100%; Query identity:100%] Prostate stem cell antigen, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	114 aa 12 kDa	No	1
PSCA-002 ENSP00000426508 ENST00000513264	H0YAA6 [Direct mapping] Prostate stem cell antigen Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		54 aa 6 kDa	No	0