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DAPK3

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GENERAL INFORMATION

Gene name

 DAPK3

Gene description

 Death-associated protein kinase 3

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA064809
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus.

Main location

 Nucleus (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA064809 CACO-2 No staining    
HPA064809 U-2 OS Nucleus
HPA064809 U-251 MG Nucleus

GENE INFORMATION

Gene name

 DAPK3 (HGNC Symbol)

Synonyms

 ZIP, ZIPK

Description

 Death-associated protein kinase 3 (HGNC Symbol)

Entrez gene summary

 Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 3958453 - 3971123

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167657 (version 83.38)

Entrez gene

 1613

UniProt

 O43293 (UniProt - Evidence at protein level)

neXtProt

 NX_O43293

Antibodypedia

 DAPK3 antibodies

PROTEIN BROWSER
DAPK3-001
DAPK3-005
DAPK3-006
DAPK3-007
DAPK3-008
DAPK3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DAPK3-001
ENSP00000442973
ENST00000545797
O43293 [Direct mapping]
Death-associated protein kinase 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005884 [actin filament]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007088 [regulation of mitotic nuclear division]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008022 [protein C-terminus binding]
GO:0008140 [cAMP response element binding protein binding]
GO:0008360 [regulation of cell shape]
GO:0010506 [regulation of autophagy]
GO:0016301 [kinase activity]
GO:0016568 [chromatin modification]
GO:0016605 [PML body]
GO:0017048 [Rho GTPase binding]
GO:0017148 [negative regulation of translation]
GO:0030182 [neuron differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043519 [regulation of myosin II filament organization]
GO:0043522 [leucine zipper domain binding]
GO:0045121 [membrane raft]
GO:0046777 [protein autophosphorylation]
GO:0051893 [regulation of focal adhesion assembly]
GO:0071346 [cellular response to interferon-gamma]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097190 [apoptotic signaling pathway]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2001241 [positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 454 aa
52.5 kDa 		No 1
DAPK3-005
ENSP00000471154
ENST00000596311
M0R0D0 [Direct mapping]
Death-associated protein kinase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 158 aa
18.4 kDa 		No 0
DAPK3-006
ENSP00000472988
ENST00000601824
M0R0D0 [Direct mapping]
Death-associated protein kinase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 158 aa
18.4 kDa 		No 0
DAPK3-007
ENSP00000470115
ENST00000593844
M0QYW5 [Direct mapping]
Death-associated protein kinase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 141 aa
16.4 kDa 		No 0
DAPK3-008
ENSP00000470168
ENST00000594894
M0QYY8 [Direct mapping]
Death-associated protein kinase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 92 aa
10 kDa 		No 0
DAPK3-201
ENSP00000301264
ENST00000301264
O43293 [Direct mapping]
Death-associated protein kinase 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007088 [regulation of mitotic nuclear division]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008140 [cAMP response element binding protein binding]
GO:0010506 [regulation of autophagy]
GO:0016568 [chromatin modification]
GO:0017048 [Rho GTPase binding]
GO:0017148 [negative regulation of translation]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043522 [leucine zipper domain binding]
GO:0046777 [protein autophosphorylation]
GO:0051893 [regulation of focal adhesion assembly]
GO:0071346 [cellular response to interferon-gamma]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 454 aa
52.5 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.