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Cancer tissues generally showed moderate cytoplasmic staining with additional membranous positivity in several cases. Follicular adenomas of thyroid and several cases of testicular cancers were strongly stained. Weak staining was observed in several cases of gliomas and cervical cancers.
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)