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NXN

CANCER ATLAS

Gene description

 Nucleoredoxin

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA023566

GENE INFORMATION

Gene name

 NXN (HGNC Symbol)

Synonyms

 FLJ12614, NRX

Description

 Nucleoredoxin (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015]

Chromosome

 17

Cytoband

 p13.3

Chromosome location (bp)

 799313 - 979770

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167693 (version 83.38)

Entrez gene

 64359

UniProt

 Q6DKJ4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6DKJ4

Antibodypedia

 NXN antibodies

PROTEIN BROWSER
NXN-001
NXN-002
NXN-003
NXN-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NXN-001
ENSP00000337443
ENST00000336868
Q6DKJ4 [Direct mapping]
Nucleoredoxin
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004791 [thioredoxin-disulfide reductase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0016055 [Wnt signaling pathway]
GO:0030154 [cell differentiation]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0047134 [protein-disulfide reductase activity]
GO:0055114 [oxidation-reduction process]
GO:0072358 [cardiovascular system development]
Show all
 435 aa
48.4 kDa 		No 0
NXN-002
ENSP00000446446
ENST00000537628
A0A0C4DGI2 [Direct mapping]
Nucleoredoxin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 186 aa
20.9 kDa 		No 0
NXN-003
ENSP00000461562
ENST00000571684
I3L4V6 [Direct mapping]
Nucleoredoxin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 230 aa
25.9 kDa 		No 0
NXN-005
ENSP00000461038
ENST00000575801
Q6DKJ4 [Direct mapping]
Nucleoredoxin
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0016055 [Wnt signaling pathway]
GO:0030154 [cell differentiation]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0047134 [protein-disulfide reductase activity]
GO:0055114 [oxidation-reduction process]
GO:0072358 [cardiovascular system development]
Show all
 327 aa
36.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.