Cell atlas - WDR81 - The Human Protein Atlas

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WDR81

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	WDR81
Gene description	WD repeat domain 81
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA023044
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA023044	A-431	Nucleoplasm
	HPA023044	U-2 OS	Nucleoplasm
	HPA023044	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	WDR81 (HGNC Symbol)
Synonyms	FLJ33817, PPP1R166
Description	WD repeat domain 81 (HGNC Symbol)
Entrez gene summary	This gene encodes a multi-domain transmembrane protein, which is predominantly expressed in the brain. Mutations in this gene are associated with autosomal recessive cerebellar ataxia, mental retardation, and dysequilibrium syndrome-2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Chromosome	17
Cytoband	p13.3
Chromosome location (bp)	1716523 - 1738599
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167716 (version 83.38)
Entrez gene	124997
UniProt	Q562E7 (UniProt - Evidence at protein level)
neXtProt	NX_Q562E7
Antibodypedia	WDR81 antibodies

PROTEIN BROWSER

WDR81-001	WDR81-002	WDR81-004	WDR81-005	WDR81-007	WDR81-009	WDR81-010	WDR81-014	WDR81-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WDR81-001 ENSP00000386609 ENST00000409644	Q562E7 [Direct mapping] WD repeat-containing protein 81 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000132 [establishment of mitotic spindle orientation] GO:0000776 [kinetochore] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005938 [cell cortex] GO:0007097 [nuclear migration] GO:0007281 [germ cell development] GO:0008017 [microtubule binding] GO:0008090 [retrograde axon cargo transport] GO:0010923 [negative regulation of phosphatase activity] GO:0022008 [neurogenesis] GO:0031023 [microtubule organizing center organization] GO:0045502 [dynein binding] GO:0047496 [vesicle transport along microtubule] GO:2000574 [regulation of microtubule motor activity] Show all	1941 aa 211.7 kDa	No	0
WDR81-002 ENSP00000312074 ENST00000309182	Q562E7 [Direct mapping] WD repeat-containing protein 81 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000132 [establishment of mitotic spindle orientation] GO:0000776 [kinetochore] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005938 [cell cortex] GO:0007097 [nuclear migration] GO:0007281 [germ cell development] GO:0008017 [microtubule binding] GO:0008090 [retrograde axon cargo transport] GO:0010923 [negative regulation of phosphatase activity] GO:0022008 [neurogenesis] GO:0031023 [microtubule organizing center organization] GO:0045502 [dynein binding] GO:0047496 [vesicle transport along microtubule] GO:2000574 [regulation of microtubule motor activity] Show all	890 aa 95.7 kDa	No	0
WDR81-004 ENSP00000401560 ENST00000446363	E9PDG3 [Direct mapping] WD repeat-containing protein 81 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	580 aa 62.7 kDa	Yes	0
WDR81-005 ENSP00000407845 ENST00000419248	Q562E7 [Direct mapping] WD repeat-containing protein 81 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000132 [establishment of mitotic spindle orientation] GO:0000776 [kinetochore] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005938 [cell cortex] GO:0007097 [nuclear migration] GO:0007281 [germ cell development] GO:0008017 [microtubule binding] GO:0008090 [retrograde axon cargo transport] GO:0010923 [negative regulation of phosphatase activity] GO:0022008 [neurogenesis] GO:0031023 [microtubule organizing center organization] GO:0045502 [dynein binding] GO:0047496 [vesicle transport along microtubule] GO:2000574 [regulation of microtubule motor activity] Show all	714 aa 77.2 kDa	No	0
WDR81-007 ENSP00000395226 ENST00000455636	C9JCF9 [Direct mapping] WD repeat-containing protein 81 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		172 aa 18.7 kDa	No	0
WDR81-009 ENSP00000460742 ENST00000468539	I3L3U7 [Direct mapping] WD repeat-containing protein 81 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		171 aa 18.9 kDa	No	0
WDR81-010 ENSP00000395198 ENST00000418841	C9JD20 [Direct mapping] WD repeat-containing protein 81 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		132 aa 14.6 kDa	No	0
WDR81-014 ENSP00000458811 ENST00000575206	I3L1G2 [Direct mapping] WD repeat-containing protein 81 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		197 aa 20.9 kDa	No	0
WDR81-201 ENSP00000391074 ENST00000437219	Q562E7 [Direct mapping] WD repeat-containing protein 81 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000132 [establishment of mitotic spindle orientation] GO:0000776 [kinetochore] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005938 [cell cortex] GO:0007097 [nuclear migration] GO:0007281 [germ cell development] GO:0008017 [microtubule binding] GO:0008090 [retrograde axon cargo transport] GO:0010923 [negative regulation of phosphatase activity] GO:0022008 [neurogenesis] GO:0031023 [microtubule organizing center organization] GO:0045502 [dynein binding] GO:0047496 [vesicle transport along microtubule] GO:2000574 [regulation of microtubule motor activity] Show all	738 aa 79.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.