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Several cases of prostate cancers, fraction of tumor cells in few cases of squamous cell carcinomas and urothelial cancers showed moderate to strong cytoplasmic staining. Additional membranous positivity was observed in few cases of skin and prostate cancers. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
KLK13 (HGNC Symbol)
Synonyms
KLK-L4
Description
Kallikrein-related peptidase 13 (HGNC Symbol)
Entrez gene summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
