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KRT80

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GENERAL INFORMATION

Gene name

 KRT80

Gene description

 Keratin 80, type II

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the intermediate filaments.

RNA cell category

 Cell line enhanced (MCF7, U-2 OS, A-431)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Intermediate filaments (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA077836 , HPA077918
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (MCF7, U-2 OS, A-431)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the intermediate filaments.

Main location

 Intermediate filaments (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA077836 A-431 Intermediate filaments
HPA077836 HaCaT Intermediate filaments Intensity
HPA077836 U-2 OS Intermediate filaments Intensity
HPA077918 A-431 Intermediate filaments Intensity
HPA077918 U-2 OS Intermediate filaments

GENE INFORMATION

Gene name

 KRT80 (HGNC Symbol)

Synonyms

 KB20

Description

 Keratin 80, type II (HGNC Symbol)

Entrez gene summary

 Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 52168996 - 52192000

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167767 (version 83.38)

Entrez gene

 144501

UniProt

 Q6KB66 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6KB66

Antibodypedia

 KRT80 antibodies

PROTEIN BROWSER
KRT80-001
KRT80-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT80-001
ENSP00000369361
ENST00000313234
Q6KB66 [Direct mapping]
Keratin, type II cytoskeletal 80
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005882 [intermediate filament]
GO:0045095 [keratin filament]
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 422 aa
47.2 kDa 		No 0
KRT80-002
ENSP00000378292
ENST00000394815
Q6KB66 [Direct mapping]
Keratin, type II cytoskeletal 80
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005882 [intermediate filament]
GO:0045095 [keratin filament]
Show all
 452 aa
50.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.