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ACER1

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GENERAL INFORMATION

Gene name

 ACER1

Gene description

 Alkaline ceramidase 1

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (T-47d)

Protein evidence

 Evidence at transcript level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 ACER1 (HGNC Symbol)

Synonyms

 ASAH3

Description

 Alkaline ceramidase 1 (HGNC Symbol)

Entrez gene summary

 Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 6306142 - 6333629

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000167769 (version 83.38)

Entrez gene

 125981

UniProt

 Q8TDN7 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8TDN7

Antibodypedia

 ACER1 antibodies

PROTEIN BROWSER
ACER1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACER1-001
ENSP00000301452
ENST00000301452
Q8TDN7 [Direct mapping]
Alkaline ceramidase 1
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Show all
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006665 [sphingolipid metabolic process]
GO:0006672 [ceramide metabolic process]
GO:0008544 [epidermis development]
GO:0010446 [response to alkaline pH]
GO:0016021 [integral component of membrane]
GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides]
GO:0017040 [ceramidase activity]
GO:0019216 [regulation of lipid metabolic process]
GO:0030148 [sphingolipid biosynthetic process]
GO:0030154 [cell differentiation]
GO:0030216 [keratinocyte differentiation]
GO:0044281 [small molecule metabolic process]
GO:0046512 [sphingosine biosynthetic process]
GO:0046514 [ceramide catabolic process]
GO:0071277 [cellular response to calcium ion]
GO:0071633 [dihydroceramidase activity]
Show all
 264 aa
31.1 kDa 		No 8

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.