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A majority of tissues showed moderate cytoplasmic staining. Hepatocellular carcinomas along with cases of lung and ovarian cancers displayed strong positivity. A majority of skin cancers, carcinoids, gliomas and lymphomas were weakly stained or negative.
Most cancers displayed weak to moderate cytoplasmic and nuclear positivity. Rare cervical and urothelial cancers showed strong positivity. Papillary adenocarcinomas of thyroid displayed additional membranous staining. Stomach and pancreatic cancers were weakly stained or negative.
GENE INFORMATION
Gene name
OTUB1 (HGNC Symbol)
Synonyms
FLJ20113, FLJ40710
Description
OTU deubiquitinase, ubiquitin aldehyde binding 1 (HGNC Symbol)
Entrez gene summary
The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)