Cell atlas - ANGPTL4 - The Human Protein Atlas

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ANGPTL4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	ANGPTL4
Gene description	Angiopoietin-like 4
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm & vesicles.
RNA cell category	Cell line enhanced (TIME, U-138 MG, LHCN-M2, U-87 MG)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA007879
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (TIME, U-138 MG, LHCN-M2, U-87 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm & vesicles.

Main location

Nucleoplasm (approved), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA007879	BJ	Nucleoplasm
	HPA007879	SiHa	Nucleoplasm
	HPA007879	SiHa	Vesicles
	HPA007879	U-2 OS	Vesicles

GENE INFORMATION
Gene name	ANGPTL4 (HGNC Symbol)
Synonyms	ARP4, FIAF, HFARP, NL2, PGAR, pp1158
Description	Angiopoietin-like 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	8363289 - 8374373
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167772 (version 83.38)
Entrez gene	51129
UniProt	Q9BY76 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BY76
Antibodypedia	ANGPTL4 antibodies

PROTEIN BROWSER

ANGPTL4-001	ANGPTL4-002	ANGPTL4-005	ANGPTL4-006	ANGPTL4-007	ANGPTL4-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANGPTL4-001 ENSP00000301455 ENST00000301455	Q9BY76 [Direct mapping] Angiopoietin-related protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001666 [response to hypoxia] GO:0004857 [enzyme inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0030154 [cell differentiation] GO:0043066 [negative regulation of apoptotic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045766 [positive regulation of angiogenesis] GO:0051005 [negative regulation of lipoprotein lipase activity] GO:0051260 [protein homooligomerization] GO:0070328 [triglyceride homeostasis] GO:0072562 [blood microparticle] GO:2000352 [negative regulation of endothelial cell apoptotic process] Show all	406 aa 45.2 kDa	Yes	0
ANGPTL4-002 ENSP00000377534 ENST00000393962	Q9BY76 [Direct mapping] Angiopoietin-related protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001666 [response to hypoxia] GO:0004857 [enzyme inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0030154 [cell differentiation] GO:0043066 [negative regulation of apoptotic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045766 [positive regulation of angiogenesis] GO:0051005 [negative regulation of lipoprotein lipase activity] GO:0070328 [triglyceride homeostasis] GO:0072562 [blood microparticle] Show all	368 aa 40.9 kDa	Yes	0
ANGPTL4-005 ENSP00000471345 ENST00000601770	M0R0N8 [Direct mapping] Angiopoietin-related protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		86 aa 8.8 kDa	Yes	0
ANGPTL4-006 ENSP00000470307 ENST00000601886	M0QZ51 [Direct mapping] Angiopoietin-related protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		96 aa 9.9 kDa	Yes	0
ANGPTL4-007 ENSP00000473090 ENST00000599192	M0R3A2 [Direct mapping] Angiopoietin-related protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		105 aa 10.9 kDa	Yes	0
ANGPTL4-008 ENSP00000472869 ENST00000594875	M0R2X8 [Direct mapping] Angiopoietin-related protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		129 aa 14.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.