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ICT1

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GENERAL INFORMATION

Gene name

 ICT1

Gene description

 Immature colon carcinoma transcript 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the mitochondria & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Mitochondria (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA003634
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the mitochondria & nucleoplasm.

Main location

 Nucleoplasm (supported), Mitochondria (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA003634 A-431 Nucleoplasm
HPA003634 A549 Nucleoplasm
Mitochondria
HPA003634 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 ICT1 (HGNC Symbol)

Synonyms

 DS-1

Description

 Immature colon carcinoma transcript 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 75012670 - 75021261

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167862 (version 83.38)

Entrez gene

 3396

UniProt

 Q14197 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14197

Antibodypedia

 ICT1 antibodies

PROTEIN BROWSER
ICT1-001
ICT1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ICT1-001
ENSP00000301585
ENST00000301585
Q14197 [Direct mapping]
Peptidyl-tRNA hydrolase ICT1, mitochondrial
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003747 [translation release factor activity]
GO:0004045 [aminoacyl-tRNA hydrolase activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0006415 [translational termination]
GO:0006996 [organelle organization]
GO:0016150 [translation release factor activity, codon nonspecific]
GO:0032543 [mitochondrial translation]
GO:0043022 [ribosome binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
GO:0072344 [rescue of stalled ribosome]
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 206 aa
23.6 kDa 		No 0
ICT1-004
ENSP00000462256
ENST00000584208
J3KS15 [Direct mapping]
Peptidyl-tRNA hydrolase ICT1, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003747 [translation release factor activity]
GO:0006415 [translational termination]
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 192 aa
21.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.