Expression of ATP5H in cancer - Summary

CANCER ATLAS

Gene description

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042777	HPA048459

GENE INFORMATION
Gene name	ATP5H (HGNC Symbol)
Synonyms	ATP5JD, ATPQ
Description	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d (HGNC Symbol)
Entrez gene summary	Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15. [provided by RefSeq, Jun 2010]
Chromosome	17
Cytoband	q25.1
Chromosome location (bp)	75038863 - 75046985
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167863 (version 83.38)
Entrez gene	10476
UniProt	O75947 (UniProt - Evidence at protein level)
neXtProt	NX_O75947
Antibodypedia	ATP5H antibodies

PROTEIN BROWSER

ATP5H-001	ATP5H-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP5H-001 ENSP00000301587 ENST00000301587	O75947 [Direct mapping] ATP synthase subunit d, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000276 [mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005753 [mitochondrial proton-transporting ATP synthase complex] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0016887 [ATPase activity] GO:0022857 [transmembrane transporter activity] GO:0022904 [respiratory electron transport chain] GO:0042776 [mitochondrial ATP synthesis coupled proton transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	161 aa 18.5 kDa	No	0
ATP5H-002 ENSP00000344230 ENST00000344546	O75947 [Direct mapping] ATP synthase subunit d, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000276 [mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005753 [mitochondrial proton-transporting ATP synthase complex] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0016887 [ATPase activity] GO:0022857 [transmembrane transporter activity] GO:0022904 [respiratory electron transport chain] GO:0042776 [mitochondrial ATP synthesis coupled proton transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	137 aa 15.8 kDa	No	0