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SRP68

GENERAL INFORMATION

Gene name

 SRP68

Gene description

 Signal recognition particle 68kDa

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA023303
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SRP68

Synonyms

Description

 Signal recognition particle 68kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 76038775 - 76072653

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167881 (version 83.38)

Entrez gene

 6730

UniProt

 Q9UHB9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHB9

Antibodypedia

 SRP68 antibodies

PROTEIN BROWSER
SRP68-001
SRP68-002
SRP68-201
SRP68-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRP68-001
ENSP00000312066
ENST00000307877
Q9UHB9 [Direct mapping]
Signal recognition particle subunit SRP68
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005047 [signal recognition particle binding]
GO:0005048 [signal sequence binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005786 [signal recognition particle, endoplasmic reticulum targeting]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005925 [focal adhesion]
GO:0006412 [translation]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0008312 [7S RNA binding]
GO:0010467 [gene expression]
GO:0030942 [endoplasmic reticulum signal peptide binding]
GO:0042493 [response to drug]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045047 [protein targeting to ER]
Show all
 627 aa
70.7 kDa 		No 0
SRP68-002
ENSP00000446136
ENST00000539137
Q9UHB9 [Direct mapping]
Signal recognition particle subunit SRP68
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005047 [signal recognition particle binding]
GO:0005048 [signal sequence binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005786 [signal recognition particle, endoplasmic reticulum targeting]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005925 [focal adhesion]
GO:0006412 [translation]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0008312 [7S RNA binding]
GO:0010467 [gene expression]
GO:0030942 [endoplasmic reticulum signal peptide binding]
GO:0042493 [response to drug]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045047 [protein targeting to ER]
Show all
 589 aa
66.1 kDa 		No 0
SRP68-201
ENSP00000473613
ENST00000602720
Q9UHB9 [Direct mapping]
Signal recognition particle subunit SRP68
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005047 [signal recognition particle binding]
GO:0005048 [signal sequence binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005786 [signal recognition particle, endoplasmic reticulum targeting]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005925 [focal adhesion]
GO:0006412 [translation]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0008312 [7S RNA binding]
GO:0010467 [gene expression]
GO:0030942 [endoplasmic reticulum signal peptide binding]
GO:0042493 [response to drug]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045047 [protein targeting to ER]
Show all
 288 aa
32.9 kDa 		No 0
SRP68-202
ENSP00000486633
ENST00000629930
K7EN53 [Direct mapping]
Signal recognition particle subunit SRP68
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005048 [signal sequence binding]
GO:0005622 [intracellular]
GO:0045047 [protein targeting to ER]
Show all
 54 aa
4.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.