Tissue expression of NLRC3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NLRC3
Gene description	NLR family, CARD domain containing 3
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lymph node)
GTEx:	Tissue enhanced (spleen)
FANTOM5:	Tissue enhanced (appendix, tonsil)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lymph node)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (appendix, tonsil)

GENE INFORMATION
Gene name	NLRC3 (HGNC Symbol)
Synonyms	CLR16.2, FLJ00348, NOD3
Description	NLR family, CARD domain containing 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	3539033 - 3577400
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167984 (version 83.38)
Entrez gene	197358
UniProt	Q7RTR2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q7RTR2
Antibodypedia	NLRC3 antibodies

PROTEIN BROWSER

NLRC3-001	NLRC3-004	NLRC3-007	NLRC3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NLRC3-001 ENSP00000352039 ENST00000359128	Q7RTR2 [Direct mapping] Protein NLRC3 C3VPR7 [Target identity:100%; Query identity:100%] NLRC3; NOD3 protein, isoform CRA_c Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0031396 [regulation of protein ubiquitination] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032496 [response to lipopolysaccharide] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0042110 [T cell activation] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] Show all	1065 aa 114.7 kDa	No	0
NLRC3-004 ENSP00000482302 ENST00000618137	A0A087WZ24 [Direct mapping] Protein NLRC3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		196 aa 20.3 kDa	No	0
NLRC3-007 ENSP00000323897 ENST00000324659	H3BLT9 [Direct mapping] NOD3 protein, isoform CRA_d; Protein NLRC3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		1112 aa 119.5 kDa	No	0
NLRC3-201 ENSP00000414415 ENST00000448023	Q7RTR2 [Direct mapping] Protein NLRC3 C3VPR7 [Target identity:100%; Query identity:100%] NLRC3; NOD3 protein, isoform CRA_c Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0042110 [T cell activation] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] Show all	1065 aa 114.7 kDa	No	0