Cell atlas - FTH1 - The Human Protein Atlas

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FTH1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules

Human cell
	Microtubules

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GENERAL INFORMATION
Gene name	FTH1
Gene description	Ferritin, heavy polypeptide 1
Protein class	Cancer-related genes Candidate cardiovascular disease genes Disease related genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubules.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. CAB008623
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubules.

Main location

Microtubules (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB008623	A-431	Microtubules
	CAB008623	U-2 OS	Microtubules
	CAB008623	U-251 MG	Microtubules

GENE INFORMATION
Gene name	FTH1 (HGNC Symbol)
Synonyms	FHC, FTH, FTHL6, PIG15, PLIF
Description	Ferritin, heavy polypeptide 1 (HGNC Symbol)
Entrez gene summary	This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q12.3
Chromosome location (bp)	61959718 - 61967660
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167996 (version 83.38)
Entrez gene	2495
UniProt	P02794 (UniProt - Evidence at protein level)
neXtProt	NX_P02794
Antibodypedia	FTH1 antibodies

PROTEIN BROWSER

FTH1-001	FTH1-003	FTH1-005	FTH1-006	FTH1-007	FTH1-010	FTH1-011	FTH1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FTH1-001 ENSP00000273550 ENST00000273550	P02794 [Direct mapping] Ferritin heavy chain Ferritin heavy chain, N-terminally processed A0A024R525 [Target identity:100%; Query identity:100%] Ferritin Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004322 [ferroxidase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006826 [iron ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0006880 [intracellular sequestering of iron ion] GO:0006892 [post-Golgi vesicle-mediated transport] GO:0006898 [receptor-mediated endocytosis] GO:0006955 [immune response] GO:0008043 [intracellular ferritin complex] GO:0008199 [ferric iron binding] GO:0008285 [negative regulation of cell proliferation] GO:0048147 [negative regulation of fibroblast proliferation] GO:0055085 [transmembrane transport] GO:0055114 [oxidation-reduction process] GO:0060547 [negative regulation of necrotic cell death] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	183 aa 21.2 kDa	No	0
FTH1-003 ENSP00000433321 ENST00000526640	G3V192 [Direct mapping] Ferritin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006826 [iron ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0008199 [ferric iron binding] Show all	153 aa 17.7 kDa	No	0
FTH1-005 ENSP00000431659 ENST00000529191	E9PK45 [Direct mapping] Ferritin heavy chain Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006826 [iron ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0008199 [ferric iron binding] Show all	102 aa 11.6 kDa	No	0
FTH1-006 ENSP00000431575 ENST00000529631	E9PKM5 [Direct mapping] Ferritin heavy chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006826 [iron ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0008199 [ferric iron binding] Show all	81 aa 9.1 kDa	No	0
FTH1-007 ENSP00000433470 ENST00000530019	E9PKY7 [Direct mapping] Ferritin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006826 [iron ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0008199 [ferric iron binding] Show all	114 aa 13.3 kDa	No	0
FTH1-010 ENSP00000435111 ENST00000532601	G3V1D1 [Direct mapping] Ferritin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006826 [iron ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0008199 [ferric iron binding] Show all	113 aa 12.9 kDa	No	0
FTH1-011 ENSP00000436947 ENST00000529548	E9PPQ4 [Direct mapping] Ferritin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006826 [iron ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0008199 [ferric iron binding] Show all	58 aa 6.7 kDa	No	0
FTH1-201 ENSP00000484477 ENST00000620041	P02794 [Direct mapping] Ferritin heavy chain Ferritin heavy chain, N-terminally processed A0A024R525 [Target identity:100%; Query identity:100%] Ferritin Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004322 [ferroxidase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006826 [iron ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0006880 [intracellular sequestering of iron ion] GO:0006892 [post-Golgi vesicle-mediated transport] GO:0006898 [receptor-mediated endocytosis] GO:0006955 [immune response] GO:0008043 [intracellular ferritin complex] GO:0008199 [ferric iron binding] GO:0008285 [negative regulation of cell proliferation] GO:0048147 [negative regulation of fibroblast proliferation] GO:0055085 [transmembrane transport] GO:0055114 [oxidation-reduction process] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	183 aa 21.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.