Tissue expression of ENTPD3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ENTPD3
Gene description	Ectonucleoside triphosphate diphosphohydrolase 3
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cervix, uterine)
GTEx:	Mixed
FANTOM5:	Tissue enhanced (pancreas, caudate, salivary gland)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cervix, uterine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pancreas, caudate, salivary gland)

GENE INFORMATION
Gene name	ENTPD3 (HGNC Symbol)
Synonyms	CD39L3, HB6, NTPDase-3
Description	Ectonucleoside triphosphate diphosphohydrolase 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014]
Chromosome	3
Cytoband	p22.1
Chromosome location (bp)	40387156 - 40428619
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168032 (version 83.38)
Entrez gene	956
UniProt	O75355 (UniProt - Evidence at protein level)
neXtProt	NX_O75355
Antibodypedia	ENTPD3 antibodies

PROTEIN BROWSER

ENTPD3-001	ENTPD3-002	ENTPD3-003	ENTPD3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ENTPD3-001 ENSP00000301825 ENST00000301825	O75355 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0009134 [nucleoside diphosphate catabolic process] GO:0009143 [nucleoside triphosphate catabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0017110 [nucleoside-diphosphatase activity] GO:0017111 [nucleoside-triphosphatase activity] Show all	529 aa 59.1 kDa	No	2
ENTPD3-002 ENSP00000401565 ENST00000456402	O75355 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] Show all	529 aa 59.1 kDa	No	2
ENTPD3-003 ENSP00000404671 ENST00000445129	O75355 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] Show all	452 aa 50.8 kDa	No	1
ENTPD3-004 ENSP00000406555 ENST00000439533	C9J0J3 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] Show all	130 aa 14.1 kDa	No	1