Expression of SLC22A11 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 22 (organic anion/urate transporter), member 11

Protein class

FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA026076

GENE INFORMATION
Gene name	SLC22A11 (HGNC Symbol)
Synonyms	OAT4
Description	Solute carrier family 22 (organic anion/urate transporter), member 11 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	64555626 - 64572875
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168065 (version 83.38)
Entrez gene	55867
UniProt	Q9NSA0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NSA0
Antibodypedia	SLC22A11 antibodies

PROTEIN BROWSER

SLC22A11-001	SLC22A11-002	SLC22A11-003	SLC22A11-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC22A11-001 ENSP00000301891 ENST00000301891	Q9NSA0 [Direct mapping] Solute carrier family 22 member 11 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005452 [inorganic anion exchanger activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008514 [organic anion transmembrane transporter activity] GO:0009897 [external side of plasma membrane] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0022857 [transmembrane transporter activity] GO:0043252 [sodium-independent organic anion transport] GO:0046415 [urate metabolic process] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098656 [anion transmembrane transport] Show all	550 aa 60 kDa	No	>9
SLC22A11-002 ENSP00000366809 ENST00000377585	Q9NSA0 [Direct mapping] Solute carrier family 22 member 11 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005452 [inorganic anion exchanger activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008514 [organic anion transmembrane transporter activity] GO:0009897 [external side of plasma membrane] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0022857 [transmembrane transporter activity] GO:0043252 [sodium-independent organic anion transport] GO:0046415 [urate metabolic process] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098656 [anion transmembrane transport] Show all	442 aa 48.3 kDa	No	8
SLC22A11-003 ENSP00000366804 ENST00000377581	A6NCG2 [Direct mapping] Solute carrier family 22 member 11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	481 aa 52.6 kDa	No	>9
SLC22A11-007 ENSP00000413508 ENST00000416590	H7C3R9 [Direct mapping] Solute carrier family 22 member 11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		153 aa 16.6 kDa	No	3