Expression of LMBRD1 in cancer - Summary

CANCER ATLAS

Gene description

LMBR1 domain containing 1

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA019547

GENE INFORMATION
Gene name	LMBRD1 (HGNC Symbol)
Synonyms	bA810I22.1, C6orf209, cblF, FLJ11240
Description	LMBR1 domain containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a lysosomal membrane protein that may be involved in the transport and metabolism of cobalamin. This protein also interacts with the large form of the hepatitis delta antigen and may be required for the nucleocytoplasmic shuttling of the hepatitis delta virus. Mutations in this gene are associated with the vitamin B12 metabolism disorder termed, homocystinuria-megaloblastic anemia complementation type F.[provided by RefSeq, Oct 2009]
Chromosome	6
Cytoband	q13
Chromosome location (bp)	69675802 - 69797111
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168216 (version 83.38)
Entrez gene	55788
UniProt	Q9NUN5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NUN5
Antibodypedia	LMBRD1 antibodies

PROTEIN BROWSER

LMBRD1-001	LMBRD1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LMBRD1-001 ENSP00000359602 ENST00000370570	Q9NUN5 [Direct mapping] Probable lysosomal cobalamin transporter Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005765 [lysosomal membrane] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0009235 [cobalamin metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031419 [cobalamin binding] GO:0044281 [small molecule metabolic process] Show all	467 aa 53.4 kDa	No	7
LMBRD1-002 ENSP00000359609 ENST00000370577	Q9NUN5 [Direct mapping] Probable lysosomal cobalamin transporter Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005158 [insulin receptor binding] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0009235 [cobalamin metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031419 [cobalamin binding] GO:0038016 [insulin receptor internalization] GO:0044281 [small molecule metabolic process] GO:0045334 [clathrin-coated endocytic vesicle] GO:0046325 [negative regulation of glucose import] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0051898 [negative regulation of protein kinase B signaling] Show all	540 aa 61.4 kDa	No	9