Cell atlas - GLYCTK - The Human Protein Atlas

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GLYCTK

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Golgi apparatus
	Rods & Rings

Human cell
	Cytosol
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	GLYCTK
Gene description	Glycerate kinase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the Golgi apparatus & rods & rings.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Additional location	In addition localized to the Golgi apparatus (approved), Rods & Rings (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA006913
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the Golgi apparatus & rods & rings.

Main location

Cytosol (supported)

Additional location

Golgi apparatus (approved), Rods & Rings (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA006913	A-431	Golgi apparatus
	HPA006913	A-431	Cytosol
	HPA006913	U-2 OS	Cytosol
	HPA006913	U-2 OS	Rods & Rings
	HPA006913	U-251 MG	Golgi apparatus
	HPA006913	U-251 MG	Cytosol

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA006913	U-2 OS	Image	U-2 OS cells were treated with Ribavirin to induce the formation of Rods & Rings. Co-localization shows that GLYCTK localizes to Rods & Rings as the staining overlaps with a marker for Rods & Rings.

GENE INFORMATION
Gene name	GLYCTK (HGNC Symbol)
Synonyms	HBEBP2, HBEBP4
Description	Glycerate kinase (HGNC Symbol)
Entrez gene summary	This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
Chromosome	3
Cytoband	p21.2
Chromosome location (bp)	52287089 - 52293476
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168237 (version 83.38)
Entrez gene	132158
UniProt	Q8IVS8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IVS8
Antibodypedia	GLYCTK antibodies

PROTEIN BROWSER

GLYCTK-002	GLYCTK-003	GLYCTK-004	GLYCTK-005	GLYCTK-009	GLYCTK-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GLYCTK-002 ENSP00000418951 ENST00000473032	Q8IVS8 [Direct mapping] Glycerate kinase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006468 [protein phosphorylation] GO:0008887 [glycerate kinase activity] Show all	205 aa 22 kDa	No	0
GLYCTK-003 ENSP00000417526 ENST00000471180	C9JA32 [Direct mapping] CG9886-like, isoform CRA_f; Glycerate kinase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		240 aa 25.1 kDa	No	0
GLYCTK-004 ENSP00000419008 ENST00000477382	Q8IVS8 [Direct mapping] Glycerate kinase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006468 [protein phosphorylation] GO:0008887 [glycerate kinase activity] Show all	234 aa 25 kDa	No	0
GLYCTK-005 ENSP00000389175 ENST00000436784	Q8IVS8 [Direct mapping] Glycerate kinase A0A024R302 [Target identity:100%; Query identity:100%] CG9886-like, isoform CRA_e Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006468 [protein phosphorylation] GO:0008887 [glycerate kinase activity] Show all	523 aa 55.3 kDa	No	0
GLYCTK-009 ENSP00000417264 ENST00000461183	C9J3N5 [Direct mapping] CG9886-like, isoform CRA_a; Glycerate kinase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		283 aa 30 kDa	No	0
GLYCTK-201 ENSP00000301965 ENST00000305690	Q8IVS8 [Direct mapping] Glycerate kinase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006468 [protein phosphorylation] GO:0008887 [glycerate kinase activity] Show all	234 aa 25 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.