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FOXI1

GENERAL INFORMATION

Gene name

 FOXI1

Gene description

 Forkhead box I1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (kidney, breast, prostate)
GTEx:Tissue enriched (kidney)
FANTOM5:Group enriched (kidney, salivary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct nuclear expression in subsets of cells in renal tubuli, salivary and mammary glands.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Cytoplasmic positivity observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA071469
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney, breast, prostate)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (kidney, salivary gland)

GENE INFORMATION

Gene name

 FOXI1 (HGNC Symbol)

Synonyms

 FKHL10, FREAC6

Description

 Forkhead box I1 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it is possible that this gene plays an important role in the development of the cochlea and vestibulum, as well as embryogenesis. Mutations in this gene may be associated with the common cavity phenotype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q35.1

Chromosome location (bp)

 170105897 - 170109725

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168269 (version 83.38)

Entrez gene

 2299

UniProt

 Q12951 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12951

Antibodypedia

 FOXI1 antibodies

PROTEIN BROWSER
FOXI1-001
FOXI1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FOXI1-001
ENSP00000304286
ENST00000306268
Q12951 [Direct mapping]
Forkhead box protein I1
E0XEN6 [Target identity:100%; Query identity:100%]
Forkhead box I1; Forkhead box I1, isoform CRA_b
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008301 [DNA binding, bending]
GO:0009790 [embryo development]
GO:0042472 [inner ear morphogenesis]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 378 aa
41 kDa 		No 0
FOXI1-002
ENSP00000415483
ENST00000449804
Q12951 [Direct mapping]
Forkhead box protein I1
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008301 [DNA binding, bending]
GO:0009790 [embryo development]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 283 aa
30.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.