Cell atlas - MPLKIP - The Human Protein Atlas

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MPLKIP

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Nucleoplasm
	Vesicles

Human cell
	Golgi Apparatus
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	MPLKIP
Gene description	M-phase specific PLK1 interacting protein
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the Golgi apparatus & vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Golgi apparatus (supported), Vesicles (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA058457 , HPA065463
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the Golgi apparatus & vesicles.

Main location

Nucleoplasm (supported)

Additional location

Golgi apparatus (supported), Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA058457	A-431	Nucleoplasm
HPA058457	A-431	Golgi apparatus
HPA058457	U-251 MG	Nucleoplasm
HPA065463	PC-3	Nucleoplasm
HPA065463	PC-3	Vesicles
HPA065463	SH-SY5Y	Nucleoplasm
HPA065463	SH-SY5Y	Vesicles
HPA065463	U-2 OS	Nucleoplasm
HPA065463	U-2 OS	Vesicles

GENE INFORMATION
Gene name	MPLKIP (HGNC Symbol)
Synonyms	C7orf11, ORF20, TTDN1
Description	M-phase specific PLK1 interacting protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009]
Chromosome	7
Cytoband	p14.1
Chromosome location (bp)	40126023 - 40134659
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168303 (version 83.38)
Entrez gene	136647
UniProt	Q8TAP9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TAP9
Antibodypedia	MPLKIP antibodies

PROTEIN BROWSER

MPLKIP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPLKIP-001 ENSP00000304553 ENST00000306984	Q8TAP9 [Direct mapping] M-phase-specific PLK1-interacting protein A4D1W6 [Target identity:100%; Query identity:100%] Chromosome 7 open reading frame 11; cDNA FLJ76008 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005813 [centrosome] GO:0007067 [mitotic nuclear division] GO:0030496 [midbody] GO:0051301 [cell division] Show all	179 aa 19.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.