Cell atlas - DEGS2 - The Human Protein Atlas

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DEGS2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	DEGS2
Gene description	Delta(4)-desaturase, sphingolipid 2
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & nucleoli.
RNA cell category	Cell line enriched (T-47d)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA046644
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (T-47d) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & nucleoli.

Main location

Nucleus (approved), Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046644	MCF7	Nucleus
	HPA046644	MCF7	Nucleoli
	HPA046644	RT4	Nucleus
	HPA046644	RT4	Nucleoli

GENE INFORMATION
Gene name	DEGS2 (HGNC Symbol)
Synonyms	C14orf66, DES2, FADS8
Description	Delta(4)-desaturase, sphingolipid 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase. [provided by RefSeq, Oct 2008]
Chromosome	14
Cytoband	q32.2
Chromosome location (bp)	100143957 - 100160163
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168350 (version 83.38)
Entrez gene	123099
UniProt	Q6QHC5 (UniProt - Evidence at protein level)
neXtProt	NX_Q6QHC5
Antibodypedia	DEGS2 antibodies

PROTEIN BROWSER

DEGS2-001	DEGS2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DEGS2-001 ENSP00000307126 ENST00000305631	Q6QHC5 [Direct mapping] Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000170 [sphingosine hydroxylase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0006667 [sphinganine metabolic process] GO:0016021 [integral component of membrane] GO:0030148 [sphingolipid biosynthetic process] GO:0042284 [sphingolipid delta-4 desaturase activity] GO:0044281 [small molecule metabolic process] GO:0046513 [ceramide biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	323 aa 37.2 kDa	No	4
DEGS2-002 ENSP00000450637 ENST00000553834	G3V2F9 [Direct mapping] Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000170 [sphingosine hydroxylase activity] GO:0006667 [sphinganine metabolic process] GO:0016021 [integral component of membrane] GO:0042284 [sphingolipid delta-4 desaturase activity] GO:0046513 [ceramide biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	54 aa 5.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.