Cell atlas - SCN11A - The Human Protein Atlas

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SCN11A

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SCN11A
Gene description	Sodium channel, voltage gated, type XI alpha subunit
Protein class	Disease related genes FDA approved drug targets Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (HDLM-2)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SCN11A (HGNC Symbol)
Synonyms	NaN, Nav1.9, SCN12A, SNS-2
Description	Sodium channel, voltage gated, type XI alpha subunit (HGNC Symbol)
Entrez gene summary	Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[supplied by OMIM, Apr 2004]
Chromosome	3
Cytoband	p22.2
Chromosome location (bp)	38845769 - 38950561
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168356 (version 83.38)
Entrez gene	11280
UniProt	Q9UI33 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UI33
Antibodypedia	SCN11A antibodies

PROTEIN BROWSER

SCN11A-001	SCN11A-002	SCN11A-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCN11A-001 ENSP00000307599 ENST00000302328	Q9UI33 [Direct mapping] Sodium channel protein type 11 subunit alpha Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Sodium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0001518 [voltage-gated sodium channel complex] GO:0005216 [ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0019228 [neuronal action potential] GO:0030424 [axon] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0042493 [response to drug] GO:0044299 [C-fiber] GO:0051930 [regulation of sensory perception of pain] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0086010 [membrane depolarization during action potential] Show all	1791 aa 204.9 kDa	No	>9
SCN11A-002 ENSP00000408028 ENST00000444237	Q9UI33 [Direct mapping] Sodium channel protein type 11 subunit alpha Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Sodium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0001518 [voltage-gated sodium channel complex] GO:0005216 [ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0019228 [neuronal action potential] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0042493 [response to drug] GO:0051930 [regulation of sensory perception of pain] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0086010 [membrane depolarization during action potential] Show all	1444 aa 165.7 kDa	No	>9
SCN11A-003 ENSP00000416757 ENST00000456224	Q9UI33 [Direct mapping] Sodium channel protein type 11 subunit alpha Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Sodium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0001518 [voltage-gated sodium channel complex] GO:0005216 [ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0019228 [neuronal action potential] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0042493 [response to drug] GO:0051930 [regulation of sensory perception of pain] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0086010 [membrane depolarization during action potential] Show all	1753 aa 200.4 kDa	No	>9

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.