Expression of KCNG4 in cancer - Summary

CANCER ATLAS

Gene description

Potassium channel, voltage gated modifier subfamily G, member 4

Protein class

Predicted membrane proteins, Voltage-gated ion channels

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039161

GENE INFORMATION
Gene name	KCNG4 (HGNC Symbol)
Synonyms	Kv6.4
Description	Potassium channel, voltage gated modifier subfamily G, member 4 (HGNC Symbol)
Entrez gene summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q24.1
Chromosome location (bp)	84218667 - 84239750
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168418 (version 83.38)
Entrez gene	93107
UniProt	Q8TDN1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TDN1
Antibodypedia	KCNG4 antibodies

PROTEIN BROWSER

KCNG4-001	KCNG4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNG4-001 ENSP00000312129 ENST00000308251	Q8TDN1 [Direct mapping] Potassium voltage-gated channel subfamily G member 4 Q547S7 [Target identity:100%; Query identity:100%] Potassium voltage-gated channel, subfamily G, member 4, isoform CRA_b; Voltage-gated potassium channel subunit Kv6.3 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0044325 [ion channel binding] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	519 aa 59 kDa	No	7
KCNG4-002 ENSP00000457897 ENST00000568181	Q8TDN1 [Direct mapping] Potassium voltage-gated channel subfamily G member 4 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005251 [delayed rectifier potassium channel activity] GO:0005886 [plasma membrane] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0044325 [ion channel binding] GO:0051260 [protein homooligomerization] GO:0071805 [potassium ion transmembrane transport] Show all	256 aa 29.3 kDa	No	1