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RHOH

CANCER ATLAS

Gene description

 Ras homolog family member H

Protein class

 Cancer-related genes, Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA030345

GENE INFORMATION

Gene name

 RHOH (HGNC Symbol)

Synonyms

 ARHH, RhoH, TTF

Description

 Ras homolog family member H (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]

Chromosome

 4

Cytoband

 p14

Chromosome location (bp)

 40191053 - 40246967

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168421 (version 83.38)

Entrez gene

 399

UniProt

 Q15669 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15669

Antibodypedia

 RHOH antibodies

PROTEIN BROWSER
«
RHOH-001
RHOH-004
RHOH-005
RHOH-006
RHOH-014
RHOH-016
RHOH-201
RHOH-202
RHOH-203
RHOH-204
RHOH-205
RHOH-206
RHOH-207
RHOH-208
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RHOH-001
ENSP00000371219
ENST00000381799
Q15669 [Direct mapping]
Rho-related GTP-binding protein RhoH
Q6ICP4 [Target identity:100%; Query identity:100%]
ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001772 [immunological synapse]
GO:0005095 [GTPase inhibitor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017048 [Rho GTPase binding]
GO:0019210 [kinase inhibitor activity]
GO:0030217 [T cell differentiation]
GO:0034260 [negative regulation of GTPase activity]
GO:0042326 [negative regulation of phosphorylation]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045576 [mast cell activation]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 191 aa
21.3 kDa 		No 0
RHOH-004
ENSP00000422241
ENST00000508513
D6R8Z1 [Direct mapping]
Rho-related GTP-binding protein RhoH
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 16 aa
1.6 kDa 		No 0
RHOH-005
ENSP00000426439
ENST00000503941
D6RG23 [Direct mapping]
Rho-related GTP-binding protein RhoH
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 103 aa
11.5 kDa 		No 0
RHOH-006
ENSP00000423384
ENST00000507851
D6RA52 [Direct mapping]
Rho-related GTP-binding protein RhoH
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 109 aa
12.1 kDa 		No 0
RHOH-014
ENSP00000420866
ENST00000511121
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 6 aa
0.7 kDa 		No 0
RHOH-016
ENSP00000425010
ENST00000505618
Q15669 [Direct mapping]
Rho-related GTP-binding protein RhoH
Q6ICP4 [Target identity:100%; Query identity:100%]
ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005095 [GTPase inhibitor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017048 [Rho GTPase binding]
GO:0019210 [kinase inhibitor activity]
GO:0030217 [T cell differentiation]
GO:0034260 [negative regulation of GTPase activity]
GO:0042326 [negative regulation of phosphorylation]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 191 aa
21.3 kDa 		No 0
RHOH-201
ENSP00000480192
ENST00000610353
Q15669 [Direct mapping]
Rho-related GTP-binding protein RhoH
Q6ICP4 [Target identity:100%; Query identity:100%]
ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005095 [GTPase inhibitor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017048 [Rho GTPase binding]
GO:0019210 [kinase inhibitor activity]
GO:0030217 [T cell differentiation]
GO:0034260 [negative regulation of GTPase activity]
GO:0042326 [negative regulation of phosphorylation]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 191 aa
21.3 kDa 		No 0
RHOH-202
ENSP00000480772
ENST00000613272
Q15669 [Direct mapping]
Rho-related GTP-binding protein RhoH
Q6ICP4 [Target identity:100%; Query identity:100%]
ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005095 [GTPase inhibitor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017048 [Rho GTPase binding]
GO:0019210 [kinase inhibitor activity]
GO:0030217 [T cell differentiation]
GO:0034260 [negative regulation of GTPase activity]
GO:0042326 [negative regulation of phosphorylation]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 191 aa
21.3 kDa 		No 0
RHOH-203
ENSP00000478248
ENST00000614836
Q15669 [Direct mapping]
Rho-related GTP-binding protein RhoH
Q6ICP4 [Target identity:100%; Query identity:100%]
ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005095 [GTPase inhibitor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017048 [Rho GTPase binding]
GO:0019210 [kinase inhibitor activity]
GO:0030217 [T cell differentiation]
GO:0034260 [negative regulation of GTPase activity]
GO:0042326 [negative regulation of phosphorylation]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 191 aa
21.3 kDa 		No 0
RHOH-204
ENSP00000480379
ENST00000615083
Q15669 [Direct mapping]
Rho-related GTP-binding protein RhoH
Q6ICP4 [Target identity:100%; Query identity:100%]
ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005095 [GTPase inhibitor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017048 [Rho GTPase binding]
GO:0019210 [kinase inhibitor activity]
GO:0030217 [T cell differentiation]
GO:0034260 [negative regulation of GTPase activity]
GO:0042326 [negative regulation of phosphorylation]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 191 aa
21.3 kDa 		No 0
RHOH-205
ENSP00000481566
ENST00000615577
Q15669 [Direct mapping]
Rho-related GTP-binding protein RhoH
Q6ICP4 [Target identity:100%; Query identity:100%]
ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005095 [GTPase inhibitor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017048 [Rho GTPase binding]
GO:0019210 [kinase inhibitor activity]
GO:0030217 [T cell differentiation]
GO:0034260 [negative regulation of GTPase activity]
GO:0042326 [negative regulation of phosphorylation]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 191 aa
21.3 kDa 		No 0
RHOH-206
ENSP00000482947
ENST00000617441
Q15669 [Direct mapping]
Rho-related GTP-binding protein RhoH
Q6ICP4 [Target identity:100%; Query identity:100%]
ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005095 [GTPase inhibitor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017048 [Rho GTPase binding]
GO:0019210 [kinase inhibitor activity]
GO:0030217 [T cell differentiation]
GO:0034260 [negative regulation of GTPase activity]
GO:0042326 [negative regulation of phosphorylation]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 191 aa
21.3 kDa 		No 0
RHOH-207
ENSP00000481746
ENST00000619474
Q15669 [Direct mapping]
Rho-related GTP-binding protein RhoH
Q6ICP4 [Target identity:100%; Query identity:100%]
ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005095 [GTPase inhibitor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017048 [Rho GTPase binding]
GO:0019210 [kinase inhibitor activity]
GO:0030217 [T cell differentiation]
GO:0034260 [negative regulation of GTPase activity]
GO:0042326 [negative regulation of phosphorylation]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 191 aa
21.3 kDa 		No 0
RHOH-208
ENSP00000481836
ENST00000622175
Q15669 [Direct mapping]
Rho-related GTP-binding protein RhoH
Q6ICP4 [Target identity:100%; Query identity:100%]
ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005095 [GTPase inhibitor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017048 [Rho GTPase binding]
GO:0019210 [kinase inhibitor activity]
GO:0030217 [T cell differentiation]
GO:0034260 [negative regulation of GTPase activity]
GO:0042326 [negative regulation of phosphorylation]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 191 aa
21.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.