Tissue expression of CDC40 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CDC40
Gene description	Cell division cycle 40
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CDC40 (HGNC Symbol)
Synonyms	EHB3, FLJ10564, PRP17, PRPF17
Description	Cell division cycle 40 (HGNC Symbol)
Entrez gene summary	Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q21
Chromosome location (bp)	110180141 - 110254275
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168438 (version 83.38)
Entrez gene	51362
UniProt	O60508 (UniProt - Evidence at protein level)
neXtProt	NX_O60508
Antibodypedia	CDC40 antibodies

PROTEIN BROWSER

CDC40-001	CDC40-005	CDC40-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDC40-001 ENSP00000357926 ENST00000368930	Q5SRN1 [Direct mapping] Pre-mRNA-processing factor 17 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	539 aa 60.8 kDa	Yes	0
CDC40-005 ENSP00000357928 ENST00000368932	O60508 [Direct mapping] Pre-mRNA-processing factor 17 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000350 [generation of catalytic spliceosome for second transesterification step] GO:0000386 [second spliceosomal transesterification activity] GO:0000398 [mRNA splicing, via spliceosome] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005681 [spliceosomal complex] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006369 [termination of RNA polymerase II transcription] GO:0006406 [mRNA export from nucleus] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0031124 [mRNA 3'-end processing] GO:0044822 [poly(A) RNA binding] GO:0071013 [catalytic step 2 spliceosome] Show all	579 aa 65.5 kDa	Yes	0
CDC40-201 ENSP00000304370 ENST00000307731	O60508 [Direct mapping] Pre-mRNA-processing factor 17 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000350 [generation of catalytic spliceosome for second transesterification step] GO:0000386 [second spliceosomal transesterification activity] GO:0000398 [mRNA splicing, via spliceosome] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005681 [spliceosomal complex] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006369 [termination of RNA polymerase II transcription] GO:0006406 [mRNA export from nucleus] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0031124 [mRNA 3'-end processing] GO:0044822 [poly(A) RNA binding] GO:0071013 [catalytic step 2 spliceosome] Show all	579 aa 65.5 kDa	Yes	0