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FEN1

GENERAL INFORMATION

Gene name

 FEN1

Gene description

 Flap structure-specific endonuclease 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in highly proliferative cells in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA006748 , CAB002262
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Vagina

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin010203040TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0510152025RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0510152025Tags Per Million

GENE INFORMATION

Gene name

 FEN1 (HGNC Symbol)

Synonyms

 FEN-1, MF1, RAD2

Description

 Flap structure-specific endonuclease 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q12.2

Chromosome location (bp)

 61792637 - 61797244

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168496 (version 83.38)

Entrez gene

 2237

UniProt

 P39748 (UniProt - Evidence at protein level)

neXtProt

 NX_P39748

Antibodypedia

 FEN1 antibodies

PROTEIN BROWSER
FEN1-001
FEN1-003
FEN1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FEN1-001
ENSP00000305480
ENST00000305885
P39748 [Direct mapping]
Flap endonuclease 1
Q6FHX6 [Target identity:100%; Query identity:100%]
Flap endonuclease 1
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000287 [magnesium ion binding]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003824 [catalytic activity]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0004523 [RNA-DNA hybrid ribonuclease activity]
GO:0004527 [exonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006302 [double-strand break repair]
GO:0007613 [memory]
GO:0008309 [double-stranded DNA exodeoxyribonuclease activity]
GO:0008409 [5'-3' exonuclease activity]
GO:0009650 [UV protection]
GO:0016020 [membrane]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0017108 [5'-flap endonuclease activity]
GO:0030145 [manganese ion binding]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0043137 [DNA replication, removal of RNA primer]
GO:0043234 [protein complex]
GO:0048256 [flap endonuclease activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
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 380 aa
42.6 kDa 		No 0
FEN1-003
ENSP00000445692
ENST00000535723
F5H1Y3 [Direct mapping]
Flap endonuclease 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004518 [nuclease activity]
GO:0006281 [DNA repair]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 165 aa
18.3 kDa 		No 0
FEN1-004
ENSP00000460402
ENST00000535307
I3L3E9 [Direct mapping]
Flap endonuclease 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003824 [catalytic activity]
GO:0004518 [nuclease activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 154 aa
17.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.