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HEXIM2

GENERAL INFORMATION

Gene name

 HEXIM2

Gene description

 Hexamethylene bis-acetamide inducible 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA023323 , HPA028455
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 HEXIM2 (HGNC Symbol)

Synonyms

 FLJ32384

Description

 Hexamethylene bis-acetamide inducible 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 45160700 - 45170040

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168517 (version 83.38)

Entrez gene

 124790

UniProt

 Q96MH2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96MH2

Antibodypedia

 HEXIM2 antibodies

PROTEIN BROWSER
HEXIM2-001
HEXIM2-002
HEXIM2-003
HEXIM2-004
HEXIM2-005
HEXIM2-006
HEXIM2-007
HEXIM2-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HEXIM2-001
ENSP00000302276
ENST00000307275
Q96MH2 [Direct mapping]
Protein HEXIM2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0017069 [snRNA binding]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 286 aa
32.4 kDa 		No 0
HEXIM2-002
ENSP00000465727
ENST00000591576
Q96MH2 [Direct mapping]
Protein HEXIM2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0017069 [snRNA binding]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 286 aa
32.4 kDa 		No 0
HEXIM2-003
ENSP00000467517
ENST00000592695
Q96MH2 [Direct mapping]
Protein HEXIM2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0017069 [snRNA binding]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 286 aa
32.4 kDa 		No 0
HEXIM2-004
ENSP00000468251
ENST00000585340
K7ERG7 [Direct mapping]
Protein HEXIM2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0017069 [snRNA binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
Show all
 204 aa
22.5 kDa 		No 0
HEXIM2-005
ENSP00000468773
ENST00000593138
K7ESM2 [Direct mapping]
Protein HEXIM2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0017069 [snRNA binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
Show all
 122 aa
13.4 kDa 		No 0
HEXIM2-006
ENSP00000465086
ENST00000586681
K7EJA3 [Direct mapping]
Protein HEXIM2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0017069 [snRNA binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
Show all
 144 aa
15.9 kDa 		No 0
HEXIM2-007
ENSP00000466200
ENST00000589230
K7ELS4 [Direct mapping]
Protein HEXIM2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0017069 [snRNA binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
Show all
 139 aa
15.3 kDa 		No 0
HEXIM2-008
ENSP00000464807
ENST00000591070
K7EIM4 [Direct mapping]
Protein HEXIM2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0017069 [snRNA binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
Show all
 79 aa
8.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.