Cell atlas - CHRM1 - The Human Protein Atlas

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CHRM1

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CHRM1
Gene description	Cholinergic receptor, muscarinic 1
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & cytosol.
RNA cell category	Cell line enhanced (MCF7, SK-BR-3, T-47d)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA014101 , CAB022366
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (MCF7, SK-BR-3, T-47d) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & cytosol.

Main location

Nucleus (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA014101	A-431	Nucleoplasm
	HPA014101	U-251 MG	Cytosol
	CAB022366	U-251 MG	Nucleus
	CAB022366	U-251 MG	Cytosol

GENE INFORMATION
Gene name	CHRM1
Synonyms
Description	Cholinergic receptor, muscarinic 1 (HGNC Symbol)
Entrez gene summary	The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q12.3
Chromosome location (bp)	62908679 - 62921807
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168539 (version 83.38)
Entrez gene	1128
UniProt	P11229 (UniProt - Evidence at protein level)
neXtProt	NX_P11229
Antibodypedia	CHRM1 antibodies

PROTEIN BROWSER

CHRM1-001	CHRM1-002	CHRM1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHRM1-001 ENSP00000306490 ENST00000306960	P11229 [Direct mapping] Muscarinic acetylcholine receptor M1 Q53XZ3 [Target identity:100%; Query identity:100%] Muscarinic acetylcholine receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004435 [phosphatidylinositol phospholipase C activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006464 [cellular protein modification process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway] GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway] GO:0007271 [synaptic transmission, cholinergic] GO:0007274 [neuromuscular synaptic transmission] GO:0007399 [nervous system development] GO:0007603 [phototransduction, visible light] GO:0007606 [sensory perception of chemical stimulus] GO:0008144 [drug binding] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0009649 [entrainment of circadian clock] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016907 [G-protein coupled acetylcholine receptor activity] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0032279 [asymmetric synapse] GO:0040012 [regulation of locomotion] GO:0043270 [positive regulation of ion transport] GO:0043679 [axon terminus] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0046541 [saliva secretion] GO:0050890 [cognition] GO:0090316 [positive regulation of intracellular protein transport] Show all	460 aa 51.4 kDa	No	7
CHRM1-002 ENSP00000441188 ENST00000543973	P11229 [Direct mapping] Muscarinic acetylcholine receptor M1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004435 [phosphatidylinositol phospholipase C activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006464 [cellular protein modification process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway] GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway] GO:0007271 [synaptic transmission, cholinergic] GO:0007399 [nervous system development] GO:0007603 [phototransduction, visible light] GO:0007606 [sensory perception of chemical stimulus] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0009649 [entrainment of circadian clock] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0043270 [positive regulation of ion transport] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0046541 [saliva secretion] GO:0050890 [cognition] Show all	454 aa 50.7 kDa	No	7
CHRM1-003 ENSP00000444482 ENST00000536524	F5GZF8 [Direct mapping] Muscarinic acetylcholine receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway] GO:0007271 [synaptic transmission, cholinergic] GO:0007606 [sensory perception of chemical stimulus] GO:0016021 [integral component of membrane] GO:0016907 [G-protein coupled acetylcholine receptor activity] GO:0030054 [cell junction] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] Show all	134 aa 14.6 kDa	No	3

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.