Expression of GFRA2 in cancer - Summary

CANCER ATLAS

Gene description

GDNF family receptor alpha 2

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Lymphoma

STAINING SUMMARY

HPA024704	CAB032791

GENE INFORMATION
Gene name	GFRA2 (HGNC Symbol)
Synonyms	GDNFRB, NTNRA, RETL2, TRNR2
Description	GDNF family receptor alpha 2 (HGNC Symbol)
Entrez gene summary	Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	21690403 - 21812357
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168546 (version 83.38)
Entrez gene	2675
UniProt	O00451 (UniProt - Evidence at transcript level)
neXtProt	NX_O00451
Antibodypedia	GFRA2 antibodies

PROTEIN BROWSER

GFRA2-001	GFRA2-003	GFRA2-004	GFRA2-005	GFRA2-006	GFRA2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GFRA2-001 ENSP00000428518 ENST00000524240	O00451 [Direct mapping] GDNF family receptor alpha-2 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399 [nervous system development] GO:0016167 [glial cell-derived neurotrophic factor receptor activity] GO:0019898 [extrinsic component of membrane] GO:0031225 [anchored component of membrane] GO:0031953 [negative regulation of protein autophosphorylation] GO:0035860 [glial cell-derived neurotrophic factor receptor signaling pathway] GO:1903263 [positive regulation of serine phosphorylation of STAT3 protein] Show all	464 aa 51.5 kDa	Yes	0
GFRA2-003 ENSP00000429206 ENST00000518077	O00451 [Direct mapping] GDNF family receptor alpha-2 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0019898 [extrinsic component of membrane] GO:0031225 [anchored component of membrane] Show all	331 aa 36.5 kDa	Yes	0
GFRA2-004 ENSP00000429979 ENST00000517892	O00451 [Direct mapping] GDNF family receptor alpha-2 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0019898 [extrinsic component of membrane] GO:0031225 [anchored component of membrane] Show all	359 aa 39.6 kDa	Yes	0
GFRA2-005 ENSP00000429445 ENST00000517328	O00451 [Direct mapping] GDNF family receptor alpha-2 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0019898 [extrinsic component of membrane] GO:0031225 [anchored component of membrane] Show all	464 aa 51.5 kDa	Yes	0
GFRA2-006 ENSP00000428721 ENST00000522071	E5RGR6 [Direct mapping] GDNF family receptor alpha-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] Show all	265 aa 30.3 kDa	Yes	0
GFRA2-007 ENSP00000430622 ENST00000519195	E5RJ44 [Direct mapping] GDNF family receptor alpha-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		74 aa 8.6 kDa	No	0