Expression of SLC20A2 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 20 (phosphate transporter), member 2

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA026540

GENE INFORMATION
Gene name	SLC20A2 (HGNC Symbol)
Synonyms	Glvr-2, GLVR2, MLVAR, PiT-2
Description	Solute carrier family 20 (phosphate transporter), member 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the inorganic phosphate transporter family. The encoded protein is a type 3 sodium-dependent phosphate symporter that plays an important role in phosphate homeostasis by mediating cellular phosphate uptake. The encoded protein also confers susceptibility to viral infection as a gamma-retroviral receptor. Mutations in this gene may play a role in familial idiopathic basal ganglia calcification. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Chromosome	8
Cytoband	p11.21
Chromosome location (bp)	42416475 - 42541926
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168575 (version 83.38)
Entrez gene	6575
UniProt	Q08357 (UniProt - Evidence at protein level)
neXtProt	NX_Q08357
Antibodypedia	SLC20A2 antibodies

PROTEIN BROWSER

SLC20A2-001	SLC20A2-002	SLC20A2-003	SLC20A2-005	SLC20A2-009	SLC20A2-010	SLC20A2-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC20A2-001 ENSP00000340465 ENST00000342228	Q08357 [Direct mapping] Sodium-dependent phosphate transporter 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0004872 [receptor activity] GO:0005315 [inorganic phosphate transmembrane transporter activity] GO:0005436 [sodium:phosphate symporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006817 [phosphate ion transport] GO:0015319 [sodium:inorganic phosphate symporter activity] GO:0016020 [membrane] GO:0035435 [phosphate ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0046718 [viral entry into host cell] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	652 aa 70.4 kDa	No	>9
SLC20A2-002 ENSP00000429754 ENST00000520262	Q08357 [Direct mapping] Sodium-dependent phosphate transporter 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0004872 [receptor activity] GO:0005315 [inorganic phosphate transmembrane transporter activity] GO:0005436 [sodium:phosphate symporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006817 [phosphate ion transport] GO:0015319 [sodium:inorganic phosphate symporter activity] GO:0016020 [membrane] GO:0035435 [phosphate ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0046718 [viral entry into host cell] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	652 aa 70.4 kDa	No	>9
SLC20A2-003 ENSP00000429712 ENST00000520179	Q08357 [Direct mapping] Sodium-dependent phosphate transporter 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0004872 [receptor activity] GO:0005315 [inorganic phosphate transmembrane transporter activity] GO:0005436 [sodium:phosphate symporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006817 [phosphate ion transport] GO:0015319 [sodium:inorganic phosphate symporter activity] GO:0016020 [membrane] GO:0035435 [phosphate ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0046718 [viral entry into host cell] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	652 aa 70.4 kDa	No	>9
SLC20A2-005 ENSP00000430166 ENST00000518717	E5RGG8 [Direct mapping] Sodium-dependent phosphate transporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005315 [inorganic phosphate transmembrane transporter activity] GO:0006817 [phosphate ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	78 aa 8.2 kDa	No	2
SLC20A2-009 ENSP00000429299 ENST00000522707	E5RIX1 [Direct mapping] Sodium-dependent phosphate transporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005315 [inorganic phosphate transmembrane transporter activity] GO:0006817 [phosphate ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	47 aa 5 kDa	No	1
SLC20A2-010 ENSP00000427756 ENST00000517366	E5RGJ6 [Direct mapping] Sodium-dependent phosphate transporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005315 [inorganic phosphate transmembrane transporter activity] GO:0006817 [phosphate ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	71 aa 7.4 kDa	No	2
SLC20A2-013 ENSP00000430462 ENST00000518384	E5RJW9 [Direct mapping] Sodium-dependent phosphate transporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005315 [inorganic phosphate transmembrane transporter activity] GO:0006817 [phosphate ion transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	28 aa 3.2 kDa	No	1