Tissue expression of ADAM18 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ADAM18
Gene description	ADAM metallopeptidase domain 18
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (testis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enriched (testis)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)

GENE INFORMATION
Gene name	ADAM18 (HGNC Symbol)
Synonyms	ADAM27, tMDCIII
Description	ADAM metallopeptidase domain 18 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Chromosome	8
Cytoband	p11.22
Chromosome location (bp)	39584489 - 39730064
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168619 (version 83.38)
Entrez gene	8749
UniProt	Q9Y3Q7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y3Q7
Antibodypedia	ADAM18 antibodies

PROTEIN BROWSER

ADAM18-001	ADAM18-004	ADAM18-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAM18-001 ENSP00000265707 ENST00000265707	Q9Y3Q7 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 18 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] Show all	739 aa 82.9 kDa	Yes	1
ADAM18-004 ENSP00000429908 ENST00000520772	Q9Y3Q7 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 18 Show all	Enzymes Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] Show all	182 aa 20.9 kDa	Yes	0
ADAM18-005 ENSP00000369195 ENST00000379866	Q9Y3Q7 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 18 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] Show all	715 aa 80.2 kDa	Yes	1