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GDNF

GENERAL INFORMATION

Gene name

 GDNF

Gene description

 Glial cell derived neurotrophic factor

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (colon, skeletal muscle)
FANTOM5:Tissue enhanced (cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in the CNS and placental syncytiotrophoblasts. Distinct expression in Purkinje cells.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. External characterization data supports antibody staining.

Reliability score

 Supported based on 1 antibody.
CAB005210
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Caudate

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION

Gene name

 GDNF (HGNC Symbol)

Synonyms

 ATF1, ATF2, HFB1-GDNF

Description

 Glial cell derived neurotrophic factor (HGNC Symbol)

Entrez gene summary

 This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq, Jun 2010]

Chromosome

 5

Cytoband

 p13.2

Chromosome location (bp)

 37812677 - 37839686

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168621 (version 83.38)

Entrez gene

 2668

UniProt

 P39905 (UniProt - Evidence at protein level)

neXtProt

 NX_P39905

Antibodypedia

 GDNF antibodies

PROTEIN BROWSER
GDNF-001
GDNF-002
GDNF-003
GDNF-004
GDNF-005
GDNF-006
GDNF-201
GDNF-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GDNF-001
ENSP00000317145
ENST00000326524
P39905 [Direct mapping]
Glial cell line-derived neurotrophic factor
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001755 [neural crest cell migration]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008344 [adult locomotory behavior]
GO:0010468 [regulation of gene expression]
GO:0021784 [postganglionic parasympathetic fiber development]
GO:0030432 [peristalsis]
GO:0031175 [neuron projection development]
GO:0032770 [positive regulation of monooxygenase activity]
GO:0033603 [positive regulation of dopamine secretion]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045597 [positive regulation of cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048255 [mRNA stabilization]
GO:0048484 [enteric nervous system development]
GO:0048485 [sympathetic nervous system development]
GO:0051584 [regulation of dopamine uptake involved in synaptic transmission]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0072107 [positive regulation of ureteric bud formation]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:2000736 [regulation of stem cell differentiation]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 211 aa
23.7 kDa 		Yes 0
GDNF-002
ENSP00000371248
ENST00000381826
P39905 [Direct mapping]
Glial cell line-derived neurotrophic factor
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001755 [neural crest cell migration]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008344 [adult locomotory behavior]
GO:0010468 [regulation of gene expression]
GO:0021784 [postganglionic parasympathetic fiber development]
GO:0030432 [peristalsis]
GO:0031175 [neuron projection development]
GO:0032770 [positive regulation of monooxygenase activity]
GO:0033603 [positive regulation of dopamine secretion]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045597 [positive regulation of cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048255 [mRNA stabilization]
GO:0048484 [enteric nervous system development]
GO:0048485 [sympathetic nervous system development]
GO:0051584 [regulation of dopamine uptake involved in synaptic transmission]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0072107 [positive regulation of ureteric bud formation]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:2000736 [regulation of stem cell differentiation]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 202 aa
22.6 kDa 		Yes 0
GDNF-003
ENSP00000425928
ENST00000515058
P39905 [Direct mapping]
Glial cell line-derived neurotrophic factor
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001755 [neural crest cell migration]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008344 [adult locomotory behavior]
GO:0010468 [regulation of gene expression]
GO:0021784 [postganglionic parasympathetic fiber development]
GO:0030432 [peristalsis]
GO:0031175 [neuron projection development]
GO:0032770 [positive regulation of monooxygenase activity]
GO:0033603 [positive regulation of dopamine secretion]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045597 [positive regulation of cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048255 [mRNA stabilization]
GO:0048484 [enteric nervous system development]
GO:0048485 [sympathetic nervous system development]
GO:0051584 [regulation of dopamine uptake involved in synaptic transmission]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0072107 [positive regulation of ureteric bud formation]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:2000736 [regulation of stem cell differentiation]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 185 aa
20.9 kDa 		Yes 0
GDNF-004
ENSP00000409007
ENST00000427982
P39905 [Direct mapping]
Glial cell line-derived neurotrophic factor
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0001656 [metanephros development]
GO:0001657 [ureteric bud development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001755 [neural crest cell migration]
GO:0001759 [organ induction]
GO:0001941 [postsynaptic membrane organization]
GO:0003337 [mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007422 [peripheral nervous system development]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008344 [adult locomotory behavior]
GO:0010468 [regulation of gene expression]
GO:0021784 [postganglionic parasympathetic fiber development]
GO:0030432 [peristalsis]
GO:0031175 [neuron projection development]
GO:0032770 [positive regulation of monooxygenase activity]
GO:0033603 [positive regulation of dopamine secretion]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045597 [positive regulation of cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048255 [mRNA stabilization]
GO:0048484 [enteric nervous system development]
GO:0048485 [sympathetic nervous system development]
GO:0051584 [regulation of dopamine uptake involved in synaptic transmission]
GO:0060676 [ureteric bud formation]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0072107 [positive regulation of ureteric bud formation]
GO:0072108 [positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:2000736 [regulation of stem cell differentiation]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 228 aa
25.5 kDa 		Yes 0
GDNF-005
ENSP00000423557
ENST00000502572
A0A0C4DGC2 [Direct mapping]
Glial cell line-derived neurotrophic factor
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
 61 aa
6.9 kDa 		Yes 0
GDNF-006
ENSP00000424592
ENST00000510177
A0A0C4DGC2 [Direct mapping]
Glial cell line-derived neurotrophic factor
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
 61 aa
6.9 kDa 		Yes 0
GDNF-201
ENSP00000339703
ENST00000344622
P39905 [Direct mapping]
Glial cell line-derived neurotrophic factor
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001755 [neural crest cell migration]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008344 [adult locomotory behavior]
GO:0010468 [regulation of gene expression]
GO:0021784 [postganglionic parasympathetic fiber development]
GO:0030432 [peristalsis]
GO:0031175 [neuron projection development]
GO:0032770 [positive regulation of monooxygenase activity]
GO:0033603 [positive regulation of dopamine secretion]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045597 [positive regulation of cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048255 [mRNA stabilization]
GO:0048484 [enteric nervous system development]
GO:0048485 [sympathetic nervous system development]
GO:0051584 [regulation of dopamine uptake involved in synaptic transmission]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0072107 [positive regulation of ureteric bud formation]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:2000736 [regulation of stem cell differentiation]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 185 aa
20.9 kDa 		Yes 0
GDNF-202
ENSP00000478722
ENST00000620847
P39905 [Direct mapping]
Glial cell line-derived neurotrophic factor
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001755 [neural crest cell migration]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008344 [adult locomotory behavior]
GO:0010468 [regulation of gene expression]
GO:0021784 [postganglionic parasympathetic fiber development]
GO:0030432 [peristalsis]
GO:0031175 [neuron projection development]
GO:0032770 [positive regulation of monooxygenase activity]
GO:0033603 [positive regulation of dopamine secretion]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045597 [positive regulation of cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048255 [mRNA stabilization]
GO:0048484 [enteric nervous system development]
GO:0048485 [sympathetic nervous system development]
GO:0051584 [regulation of dopamine uptake involved in synaptic transmission]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0072107 [positive regulation of ureteric bud formation]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:2000736 [regulation of stem cell differentiation]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 159 aa
18.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.