Expression of TET2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Tet methylcytosine dioxygenase 2

Protein class

Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043135

GENE INFORMATION
Gene name	TET2 (HGNC Symbol)
Synonyms	FLJ20032, KIAA1546
Description	Tet methylcytosine dioxygenase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Chromosome	4
Cytoband	q24
Chromosome location (bp)	105145875 - 105279816
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168769 (version 83.38)
Entrez gene	54790
UniProt	Q6N021 (UniProt - Evidence at protein level)
neXtProt	NX_Q6N021
Antibodypedia	TET2 antibodies

PROTEIN BROWSER

TET2-001	TET2-002	TET2-003	TET2-004	TET2-006	TET2-201	TET2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TET2-001 ENSP00000306705 ENST00000305737	Q6N021 [Direct mapping] Methylcytosine dioxygenase TET2 A0A024RDF7 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0006211 [5-methylcytosine catabolic process] GO:0006493 [protein O-linked glycosylation] GO:0007049 [cell cycle] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030099 [myeloid cell differentiation] GO:0035511 [oxidative DNA demethylation] GO:0040029 [regulation of gene expression, epigenetic] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0070579 [methylcytosine dioxygenase activity] GO:0080111 [DNA demethylation] GO:0080182 [histone H3-K4 trimethylation] Show all	1165 aa 130.3 kDa	No	0
TET2-002 ENSP00000369351 ENST00000380013	Q6N021 [Direct mapping] Methylcytosine dioxygenase TET2 Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0006211 [5-methylcytosine catabolic process] GO:0006493 [protein O-linked glycosylation] GO:0007049 [cell cycle] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030099 [myeloid cell differentiation] GO:0035511 [oxidative DNA demethylation] GO:0040029 [regulation of gene expression, epigenetic] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0070579 [methylcytosine dioxygenase activity] GO:0080111 [DNA demethylation] GO:0080182 [histone H3-K4 trimethylation] Show all	2002 aa 223.8 kDa	No	0
TET2-003 ENSP00000425443 ENST00000513237	E7EQS8 [Direct mapping] Methylcytosine dioxygenase TET2 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	2023 aa 226.1 kDa	No	0
TET2-004 ENSP00000391448 ENST00000413648	E7EPB1 [Direct mapping] Methylcytosine dioxygenase TET2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		1167 aa 130.5 kDa	No	0
TET2-006 ENSP00000426885 ENST00000514870	D6RE87 [Direct mapping] Methylcytosine dioxygenase TET2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		110 aa 12.2 kDa	No	0
TET2-201 ENSP00000378245 ENST00000394764	A0A0A0MS53 [Direct mapping] Methylcytosine dioxygenase TET2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		637 aa 69.9 kDa	No	0
TET2-202 ENSP00000442788 ENST00000540549	Q6N021 [Direct mapping] Methylcytosine dioxygenase TET2 Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0002318 [myeloid progenitor cell differentiation] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0006211 [5-methylcytosine catabolic process] GO:0006493 [protein O-linked glycosylation] GO:0007049 [cell cycle] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0009791 [post-embryonic development] GO:0010467 [gene expression] GO:0014070 [response to organic cyclic compound] GO:0019857 [5-methylcytosine metabolic process] GO:0019858 [cytosine metabolic process] GO:0020027 [hemoglobin metabolic process] GO:0030097 [hemopoiesis] GO:0030099 [myeloid cell differentiation] GO:0035511 [oxidative DNA demethylation] GO:0040029 [regulation of gene expression, epigenetic] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048536 [spleen development] GO:0048872 [homeostasis of number of cells] GO:0061484 [hematopoietic stem cell homeostasis] GO:0070579 [methylcytosine dioxygenase activity] GO:0072576 [liver morphogenesis] GO:0080111 [DNA demethylation] GO:0080182 [histone H3-K4 trimethylation] Show all	2002 aa 223.8 kDa	No	0